Large Differences between LINE-1 Amplification Rates in the Human and Chimpanzee Lineages
| Autor: | Igor V. Ovchinnikov, Noam Greenberg, Lauren M. Mathews, Gary D. Swergold, Susan Y. Chi |
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| Rok vydání: | 2003 |
| Předmět: |
0106 biological sciences
Subfamily Pan troglodytes Molecular Sequence Data Retrotransposon Biology 010603 evolutionary biology 01 natural sciences Genome 03 medical and health sciences Species Specificity Phylogenetics Report Gene duplication Genetics Animals Humans Genetics(clinical) Phylogeny Genetics (clinical) 030304 developmental biology 0303 health sciences Base Sequence Phylogenetic tree Gene Amplification Chromosome Mapping Pan paniscus Long interspersed nuclear element Long Interspersed Nucleotide Elements |
| Zdroj: | The American Journal of Human Genetics. 72:739-748 |
| ISSN: | 0002-9297 |
| DOI: | 10.1086/368275 |
| Popis: | The genomic evolution and causes of phenotypic variation among humans and great apes remain largely unknown, although the phylogenetic relationships among them have been extensively explored. Previous studies that focus on differences at the amino acid and nucleotide sequence levels have revealed a high degree of similarity between humans and chimpanzees, suggesting that other types of genomic change may have contributed to the relatively large phenotypic differences between them. For example, the activity of long interspersed element 1 (LINE-1) retrotransposons may impose significant changes on genomic structure and function and, consequently, on phenotype. Here we investigate the relative rates of LINE-1 amplification in the lineages leading to humans, bonobos (Pan paniscus), and chimpanzees (P. troglodytes). Our data indicate that LINE-1 insertions have accumulated at significantly greater rates in bonobos and chimpanzees than in humans, provide insights into the timing of major LINE-1 amplification events during great ape evolution, and identify a Pan-specific LINE-1 subfamily. |
| Databáze: | OpenAIRE |
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