The Risk of Acute Myocardial Infarction in Patients With Gastroesophageal Reflux Disease
| Autor: | Annumeet Sandhu, Mohamed Eisa, Stephen J. Ganocy, Ravi Prakash, Ronnie Fass |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Population Gastroesophageal reflux disease Coronary artery disease 03 medical and health sciences 0302 clinical medicine Diabetes mellitus Internal medicine Medicine Cloud computing Myocardial infarction Risk factor education education.field_of_study business.industry Incidence (epidemiology) Gastroenterology Inflammation mediators medicine.disease digestive system diseases 030220 oncology & carcinogenesis Cohort GERD 030211 gastroenterology & hepatology Original Article Neurology (clinical) business |
| Zdroj: | Journal of Neurogastroenterology and Motility |
| ISSN: | 2093-0887 2093-0879 |
| Popis: | Background/Aims A number of inflammatory mediators have been documented to be elevated in gastroesophageal reflux disease (GERD). Similar inflammatory mediators are involved in coronary artery disease. Thus, the aim of the study is to determine if GERD is a risk factor for developing acute myocardial infarction (AMI). Methods We used Explorys, a private cloud-based data store to which a number of health care systems feed information. We identified a cohort of GERD patients who have undergone an esophagogastroduodenoscopy compared to those without GERD. Incidence of AMI was studied after statistically controlling for known AMI risk factors. Results Total of 200 400 patients were included in the GERD group and 386 800 patients in non-GERD group. The primary event of AMI occurred in 17 200 patients in the GERD group (8.6%) vs 24 300 in non-GERD group (6.3%). Using logistic regression analysis and controlling for 6 major risk factors which included male gender (OR, 1.09; 95% CI, 1.07-1.11; P < 0.001), hypertension (OR, 6.53; 95% CI, 6.21-6.88; P < 0.001), hyperlipidemia (OR, 3.08; 95% CI, 2.96-3.20; P < 0.001), diabetes mellitus (OR, 1.72; 95% CI, 1.69- 1.76; P < 0.001), obesity (OR, 1.02; 95% CI, 1.00-1.04; P = 0.044), and smoking (OR, 1.38; 95% CI, 1.35-1.41; P < 0.001). The odds of developing AMI in the GERD population was 1.11 (95% CI, 1.08-1.13; P < 0.001). GERD had higher odds of developing AMI than male gender or obesity in our study. Conclusions This study demonstrated that GERD is a risk factor for AMI, higher than male gender and obesity. However, the increased risk may be clinically insignificant. (J Neurogastroenterol Motil 2020;26:471-476) |
| Databáze: | OpenAIRE |
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