The Health & Aging Brain among Latino Elders (HABLE) study methods and participant characteristics
| Autor: | Rocky Vig, Raymond F. Palmer, Deydeep Kothapalli, Raul Vintimilla, Sid E. O'Bryant, Fan Zhang, Yonggang Shi, Meredith N. Braskie, Kristine Yaffe, Bradley T. Christian, Stephanie Large, James Hall, Elizabeth Matsiyevskiy, David C. Mason, Melissa Petersen, Rajesh Nandy, Arthur W. Toga, Kevin S. King, Robert A. Rissman, Roderick W McColl, Leigh Johnson, Nalini Hazra, Nicole Philips, Robert Barber |
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| Rok vydání: | 2021 |
| Předmět: |
Gerontology
Significant group Hispanic Mexican americans diversity 03 medical and health sciences mild cognitive impairment 0302 clinical medicine Study methods Aging brain RC346-429 Diagnostic Assessment & Prognosis 030304 developmental biology 0303 health sciences neurodegeneration RC952-954.6 amyloid biomarkers Alzheimer's disease Psychiatry and Mental health Mexican American Geriatrics Neurology. Diseases of the nervous system Neurology (clinical) Neuropsychological testing Psychology 030217 neurology & neurosurgery Research Article |
| Zdroj: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 13, Iss 1, Pp n/a-n/a (2021) Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring |
| ISSN: | 2352-8729 |
| Popis: | Author(s): O'Bryant, Sid E; Johnson, Leigh A; Barber, Robert C; Braskie, Meredith N; Christian, Bradley; Hall, James R; Hazra, Nalini; King, Kevin; Kothapalli, Deydeep; Large, Stephanie; Mason, David; Matsiyevskiy, Elizabeth; McColl, Roderick; Nandy, Rajesh; Palmer, Raymond; Petersen, Melissa; Philips, Nicole; Rissman, Robert A; Shi, Yonggang; Toga, Arthur W; Vintimilla, Raul; Vig, Rocky; Zhang, Fan; Yaffe, Kristine; HABLE Study Team | Abstract: IntroductionMexican Americans remain severely underrepresented in Alzheimer's disease (AD) research. The Health a Aging Brain among Latino Elders (HABLE) study was created to fill important gaps in the existing literature.MethodsCommunity-dwelling Mexican Americans and non-Hispanic White adults and elders (age 50 and above) were recruited. All participants underwent comprehensive assessments including an interview, functional exam, clinical labs, informant interview, neuropsychological testing, and 3T magnetic resonance imaging (MRI) of the brain. Amyloid and tau positron emission tomography (PET) scans were added at visit 2. Blood samples were stored in the Biorepository.ResultsData was examined from nn=n1705 participants. Significant group differences were found in medical, demographic, and sociocultural factors. Cerebral amyloid and neurodegeneration imaging markers were significantly different between Mexican Americans and non-Hispanic Whites.DiscussionThe current data provide strong support for continued investigations that examine the risk factors for and biomarkers of AD among diverse populations. |
| Databáze: | OpenAIRE |
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