Changes in rat cerebral blood volume due to modulation of the 5-HT(1A) receptor measured with susceptibility enhanced contrast MRI
| Autor: | John C. Gore, B. Ellen Scanley, Richard P. Kennan |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Agonist
medicine.medical_specialty Serotonin medicine.drug_class Pyridines Central nervous system Hippocampus Contrast Media Blood volume Blood Pressure Piperazines Rats Sprague-Dawley Internal medicine Cortex (anatomy) polycyclic compounds medicine Animals heterocyclic compounds Drug Interactions Receptor Molecular Biology Neurons 8-Hydroxy-2-(di-n-propylamino)tetralin Blood Volume Dose-Response Relationship Drug Chemistry musculoskeletal neural and ocular physiology General Neuroscience Antagonist Brain Magnetic Resonance Imaging Rats Serotonin Receptor Agonists medicine.anatomical_structure Endocrinology nervous system Cerebrovascular Circulation Receptors Serotonin 5-HT1A receptor Female Neurology (clinical) Serotonin Antagonists Receptors Serotonin 5-HT1 Developmental Biology |
| Zdroj: | Brain research. 913(2) |
| ISSN: | 0006-8993 |
| Popis: | Brain blood volume changes in the rat in response to 5-HT1A agonist and antagonist administration were measured using susceptibility contrast enhanced magnetic resonance imaging (MRI). Administration of the 5-HT1A agonist 8-OH-DPAT resulted in decreases in fractional brain blood volumes. Administration of the 5-HT1A antagonist WAY-100635 following a dose of 8-OH-DPAT resulted in increases in fractional blood volumes greatest in hippocampus and cortex and smallest in thalamus and caudate-putamen. The magnitude of the regional increases in blood volumes paralleled the distribution of 5-HT1A receptors in the rat brain. Administration of WAY-100635 alone resulted in decreases in cortical blood volume and increases in cerebellar blood volume. |
| Databáze: | OpenAIRE |
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