Vasculogenic mimicry in small cell lung cancer
| Autor: | Christopher P. E. Chester, Hui Sun Leong, Nicole Simms, Peter Kuhn, Lynsey Priest, Fiona H Blackhall, Alberto Fusi, Sumitra Mohan, Benjamin Abbott, Mary J.C. Hendrix, Ged Brady, Richard E.B. Seftor, Radoslaw Polanski, Anders Carlsson, Fredrika Carlsson, Robert Metcalf, Elisabeth A. Seftor, Francesca Trapani, SC Williamson, Caroline Dive, Jenny Antonello, Andrew Hughes, Kathryn Simpson, Daisuke Nonaka, Crispin J. Miller, Dominic G. Rothwell, James W. Hicks |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Lung Neoplasms Biopsy General Physics and Astronomy Metastasis Cohort Studies Neovascularization Mice 0302 clinical medicine Single-cell analysis Lung Multidisciplinary Neovascularization Pathologic Manchester Cancer Research Centre medicine.diagnostic_test Middle Aged Cadherins Neoplastic Cells Circulating 3. Good health 030220 oncology & carcinogenesis Keratins Female Small Cell Lung Carcinoma Single-Cell Analysis medicine.symptom medicine.drug DNA Copy Number Variations Science Biology Article General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Antigens CD Cell Line Tumor medicine Animals Humans Vasculogenic mimicry neoplasms Cisplatin Cadherin ResearchInstitutes_Networks_Beacons/mcrc General Chemistry medicine.disease Xenograft Model Antitumor Assays respiratory tract diseases 030104 developmental biology Mutation Immunology Cancer research Tumor Suppressor Protein p53 |
| Zdroj: | Williamson, S C, Metcalf, R L, Trapani, F, Mohan, S, Antonello, J, Abbott, B, Leong, H S, Chester, C, Simms, N, Polanski, R, Nonaka, D, Priest, L, Fusi, A, Carlsson, F, Carlsson, A, Hendrix, M J C, Seftor, R E B, Seftor, E A, Rothwell, D G, Hughes, A, Hicks, J, Miller, C, Kuhn, P, Brady, G, Simpson, K L, Blackhall, F H & Dive, C 2016, ' Vasculogenic mimicry in small cell lung cancer ', Nature Communications, vol. 7, pp. 13322 . https://doi.org/10.1038/ncomms13322, https://doi.org/10.1038/ncomms13322 Nature Communications Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016) Trapani, F, Metcalf, R L, Hodgkinson, C L, Polanski, R, Bola, B, Nonaka, D, Fusi, A, Priest, L, Hendrix, M J C, Seftor, R E B, Seftor, E A, Morrow, C J, Antonello, J, Brady, G, Miller, C, Leong, H S, Rothwell, D, Blackhall, F, Williamson, S, Dive, C & Simpson, K L 2015, ' Vasculogenic Mimicry in Small Cell Lung Cancer ', Journal of Thoracic Oncology, vol. 10, no. 9 . https://doi.org/10.1038/ncomms13322 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/ncomms13322 |
| Popis: | Small cell lung cancer (SCLC) is characterized by prevalent circulating tumour cells (CTCs), early metastasis and poor prognosis. We show that SCLC patients (37/38) have rare CTC subpopulations co-expressing vascular endothelial-cadherin (VE-cadherin) and cytokeratins consistent with vasculogenic mimicry (VM), a process whereby tumour cells form ‘endothelial-like' vessels. Single-cell genomic analysis reveals characteristic SCLC genomic changes in both VE-cadherin-positive and -negative CTCs. Higher levels of VM are associated with worse overall survival in 41 limited-stage patients' biopsies (P Small cell lung cancer (SCLC) is characterised by prevalent circulating tumour cells (CTCs), early metastasis and poor prognosis. The authors show that SCLC patients have a rare CTC subset with a vasculogenic mimicry (VM) phenotype, and that VM is associated with worse overall survival, and alters tumour growth, chemotherapy delivery and efficacy. |
| Databáze: | OpenAIRE |
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