Water-soluble and reusable Ru-NHC catalyst for aqueous-phase transfer hydrogenation of quinolines with formic acid
| Autor: | Babulal Maji, Anirban Bhandari, Rayantan Sadhukhan, Joyanta Choudhury |
|---|---|
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Dalton Transactions. 51:8258-8265 |
| ISSN: | 1477-9234 1477-9226 |
| Popis: | Water-soluble Ru-NHC complexes were synthesized and their catalytic activity was tested in the transfer hydrogenation of quinoline-type N-heteroarenes using a formic acid/sodium formate buffer solution. The unique multifunctional features of the designed ligand within the catalyst backbone endowed it with excellent durability, reusability and compatibility with a simple aqueous-phase operation. Thus, it was possible to reuse as little as 0.25 mol% of the catalyst for three consecutive catalytic runs to provide an overall turnover number of around 900. A mechanistic investigation suggested that hydride generation was the rate-limiting step, whereas hydride transfer was relatively facile. Furthermore, computational studies supported that the reaction pathway was dominated by 1,4-hydride insertion at the N-heteroarene substrates. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|