Tenascin-C in primary Merkel cell carcinoma
| Autor: | G Granroth, Tom Böhling, Caj Haglund, Tiina Jahkola, Virve Koljonen, Erkki Tukiainen |
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| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Pathology Skin Neoplasms Connective tissue Tenascin Pathology and Forensic Medicine Immunoenzyme Techniques 03 medical and health sciences 0302 clinical medicine Biomarkers Tumor medicine Carcinoma Humans Neoplasm Invasiveness Aged 030304 developmental biology Aged 80 and over 0303 health sciences biology Merkel cell carcinoma Tenascin C Anatomical pathology Original Articles General Medicine Middle Aged Prognosis medicine.disease Neoplasm Proteins 3. Good health Carcinoma Merkel Cell medicine.anatomical_structure 030220 oncology & carcinogenesis biology.protein Immunohistochemistry Female Merkel cell Cell Division |
| Zdroj: | Journal of Clinical Pathology. 58:297-300 |
| ISSN: | 0021-9746 |
| DOI: | 10.1136/jcp.2004.018432 |
| Popis: | Background/Aims: Merkel cell carcinoma (MCC) is a rare malignant cutaneous neuroendocrine tumour that mostly affects the elderly. It shows rapid progression of the primary tumour, together with a vertical growth pattern into the underlying subcutaneous tissue. Metastatic dissemination to regional lymph nodes is early and frequent. Tenascin-C (Tn-C) is a large extracellular matrix glycoprotein that is expressed in various benign and malignant processes. Expression of Tn-C is also associated with invasion and cellular proliferation, and is often downregulated in fully evolved advanced carcinomas. In previous studies, Tn-C expression correlated with prognosis in tumours of different origin. Methods: Immunohistochemistry was used to investigate the expression of Tn-C in 25 MCC specimens and to evaluate the prognostic importance of this glycoprotein. Results: Seventeen samples expressed Tn-C. Staining was mainly seen in the invasion borders and within the connective tissue septae inside the tumours. The expression of Tn-C correlated significantly with large tumour size. There was also frequent expression of Tn-C in primary tumours with metastatic dissemination. Most of the Tn-C negative samples were of small size. Conclusions: Tn-C expression seems to increase with tumour size and malignant behaviour. Expression was slightly enhanced in tumours with high proliferative indices. Expression is seen mainly in areas of invasive growth and, in this respect, resembles that of other invasive tumours. |
| Databáze: | OpenAIRE |
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