Overexpression of Tie2 is associated with poor prognosis in patients with gastric cancer
| Autor: | Pei‑Wu Yu, Wei‑Jun Yang, Yan Shi, Xiao‑Lan Fu, Hao‑Lin Dong, Peng Yin, Xia Yang, Ying‑Xue Hao, Hai‑Ling Yue |
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| Rok vydání: | 2015 |
| Předmět: |
Cancer Research
medicine.medical_specialty 010304 chemical physics Oncogene Cluster of differentiation business.industry CD68 Cancer Articles Cell cycle medicine.disease 01 natural sciences Gastroenterology Molecular medicine 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Oncology Internal medicine 0103 physical sciences medicine Immunohistochemistry 030212 general & internal medicine business Lymph node |
| Zdroj: | Oncology letters. 15(5) |
| ISSN: | 1792-1074 |
| Popis: | Tunica Interna endothelial cell kinase (Tie2)-expressing macrophages (TEMs) are a subgroup of tumor-associated macrophages that are associated with a poor prognosis in numerous types of cancer. The present study aimed to assess the prognostic impact of Tie2 expression in gastric cancer tissues. Between January 2009 and December 2009, 76 newly diagnosed patients with gastric cancer at the Southwest Hospital, Third Military Medical University (Chongqing, China) were enrolled. TEMs were detected using immunohistochemistry. Tie2, cluster of differentiation (CD)68 and carbonic anhydrase IX (CAIX) were analyzed using immunohistochemistry and immunofluorescent microscopy. Tie2 protein expression was analyzed using western blot analysis in hypoxic and normoxic gastric cancer tissues. The number of TEMs positively staining for Tie2 increased with the tumor-node-metastasis (TNM) stage: 0, 53.9, 75.6 and 100% in stages I, II, III and IV, respectively (P |
| Databáze: | OpenAIRE |
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