Clinical significance of BPI‐ANCA detecting in COPD patients with Pseudomonas aeruginosa colonization

Autor: Jiayi Huang, Tingting Zeng, Z Pei, Yongjian Tian, Jianlin Yu, Yang Wu, Liming Tan
Rok vydání: 2019
Předmět:
Male
0301 basic medicine
Interleukin-1beta
Clinical Biochemistry
medicine.disease_cause
Gastroenterology
Pulmonary Disease
Chronic Obstructive
0302 clinical medicine
Immunology and Allergy
Research Articles
COPD
Interleukin
Blood Proteins
Hematology
Middle Aged
respiratory system
humanities
Respiratory Function Tests
Medical Laboratory Technology
medicine.anatomical_structure
030220 oncology & carcinogenesis
Pseudomonas aeruginosa
Female
Tumor necrosis factor alpha
Research Article
Microbiology (medical)
medicine.medical_specialty
Antibodies
Antineutrophil Cytoplasmic
chronic obstructive pulmonary disease
antineutrophil cytoplasm autoantibodies
03 medical and health sciences
FEV1/FVC ratio
Internal medicine
medicine
Humans
Pseudomonas Infections
Clinical significance
cardiovascular diseases
bactericidal/permeability‐increasing protein
Aged
Retrospective Studies
Lung
Interleukin-6
Tumor Necrosis Factor-alpha
business.industry
Biochemistry (medical)
Public Health
Environmental and Occupational Health
Autoantibody
medicine.disease
cytokines
respiratory tract diseases
030104 developmental biology
Case-Control Studies
business
Antimicrobial Cationic Peptides
Zdroj: Journal of Clinical Laboratory Analysis
ISSN: 1098-2825
0887-8013
DOI: 10.1002/jcla.22908
Popis: Background Antineutrophil cytoplasmic autoantibodies against neutrophil granule bactericidal/permeability-increasing protein (BPI-ANCA) has been found in many inflammatory diseases, such as COPD, which can reduce the killing effect of BPI on Gram-negative bacteria. This study was aimed to assess the clinical significance of BPI-ANCA detecting in COPD patients with Pseudomonas aeruginosa (P aeruginosa) colonization. Methods A total of 216 COPD patients with lung P aeruginosa colonization, 244 patients with P aeruginosa infection from June 2015 to June 2018, and 100 healthy individuals were included. Serum BPI-ANCA, tumor necrosis factor (TNF)-α, and interleukin (IL)-6 and IL-1β levels were detected by ELISA, and the lung function of the patients was measured at stable clinical stages. Patients with COPD were grouped according to BPI-ANCA detection and GOLD criteria, and serum TNF-α, IL-6, and IL-1β levels and indices reflecting lung function were compared and analyzed between groups. Results Positive rate of BPI-ANCA in COPD patients with P aeruginosa colonization was 48.15%; and compared with BPI-ANCA(-) group, FEV1 %pred and FEV1 /FVC(%) in BPI-ANCA(+) patients were significantly decreased, while TNF-α, IL-6, and IL-1β levels were elevated. There were 31.73% and 36.54% BPI-ANCA(+) patients with severe and very severe airflow limitation, respectively, which was significantly higher than that in the BPI-ANCA(-) group. FEV1 %pred and FEV1 /FVC(%) were negatively correlated with TNF-α, IL-6, IL-1β, and NEU%. C-reactive protein (CRP) was negatively correlated with FEV1 %pred, yet not significantly correlated with FEV1 /FVC(%). Conclusion BPI-ANCA positivity is associated with inflammatory status in COPD patients with pulmonary P aeruginosa colonization and can be used as a potential biomarker assessing disease severity.
Databáze: OpenAIRE
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