In vivo characterization of coronary plaques: novel findings from comparing greyscale and virtual histology intravascular ultrasound and near-infrared spectroscopy
| Autor: | Emmanouil S. Brilakis, Sinan Biro, Jin Bae Lee, Gary S. Mintz, Akiko Maehara, Subhash Banerjee, Giora Weisz, Gregg W. Stone, Jun Pu, Brijeshwar Maini, Abdul Rahman R Abdel-Karim |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Pathology medicine.medical_specialty Coronary Artery Disease Coronary artery disease Virtual histology intravascular ultrasound In vivo Coronary plaque Intravascular ultrasound Image Processing Computer-Assisted medicine Humans In patient Ultrasonography Interventional Aged Spectroscopy Near-Infrared medicine.diagnostic_test business.industry Histology Middle Aged equipment and supplies medicine.disease Plaque Atherosclerotic surgical procedures operative Female Cardiology and Cardiovascular Medicine Lipid core business |
| Zdroj: | European Heart Journal. 33:372-383 |
| ISSN: | 1522-9645 0195-668X |
| Popis: | Aims To test the hypothesis that near-infrared spectroscopy (NIRS) combined with intravascular ultrasound (IVUS) would provide novel information of human coronary plaque characterization. Methods and results Greyscale-IVUS, virtual histology (VH)-IVUS, and NIRS were compared in 131 native lesions (66 vessels) that were interrogated during catheterization by all three modalities. Greyscale-IVUS detected attenuated and echolucent plaques correlated with NIRS-detected lipid-rich areas. Attenuated plaques contained the highest NIRS probability of lipid core, followed by echolucent plaques. By VH-IVUS, 93.5% of attenuated plaques contained confluent necrotic core (NC) and were classified as VH-derived fibroatheromas (FAs). Although 75.0% of echolucent plaques were classified as VH-FAs, VH-NC was seen surrounding an echolucent zone, but not within any echolucent zone; and echolucent zones themselves contained fibrofatty and/or fibrous tissue. All calcified plaques with arc >90° contained >10% VH-NC (range 16.0–41.2%) and were classified as calcified VH-FAs, but only 58.5% contained NIRS-detected lipid core. A positive relationship between VH-derived %NC and NIRS-derived lipid core burden index was found in non-calcified plaques, but not in calcified plaques. Conclusion Combining NIRS with IVUS contributes to the understanding of plaque characterization in vivo . Further studies are warranted to determine whether combining NIRS and IVUS will contribute to the assessment of high-risk plaques to predict outcomes in patients with coronary artery disease. |
| Databáze: | OpenAIRE |
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