Mosaic representations of odors in the input and output layers of the mouse olfactory bulb
| Autor: | Venkatesh N. Murthy, Walter G Bast, Alexei A. Koulakov, Honggoo Chae, Daniel Kepple, Dinu F. Albeanu |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Olfactory system Male Sensory Receptor Cells Stimulus (physiology) Biology Mouse Olfactory Bulb Article 03 medical and health sciences Mice 0302 clinical medicine Animals Feedback Physiological Extramural General Neuroscience Olfactory Pathways Olfactory Bulb Olfactory bulb Smell 030104 developmental biology Tufted cell Odor Odor recognition Odorants Female Neuroscience 030217 neurology & neurosurgery psychological phenomena and processes |
| Zdroj: | Nat Neurosci |
| Popis: | The elementary stimulus features encoded by the olfactory system remain poorly understood. We examined the relationship between 1,666 physical-chemical descriptors of odors and the activity of olfactory bulb inputs as well as outputs in awake mice. Glomerular and M/T cell responses were sparse and locally heterogeneous, with only a coarse dependence of glomerular positions on physical-chemical properties. Odor features represented by ensembles of M/T cells were overlapping, but distinct from those represented in glomeruli, consistent with extensive interplay between feedforward and feedback inputs to the bulb. This reformatting was well-described as a rotation in odor space. The descriptors accounted for a small fraction in response variance, and the similarity of odors in physical-chemical space was a poor predictor of similarity in neuronal representations. Our results suggest that commonly used physical-chemical properties are not systematically represented in bulbar activity and encourage further search for better descriptors of odor space. |
| Databáze: | OpenAIRE |
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