Sensitivity of transcription factors to DNA methylation
| Autor: | Anaïs F. Bardet, Eléa Héberlé |
|---|---|
| Přispěvatelé: | Biotechnologie et signalisation cellulaire (BSC), Université de Strasbourg (UNISTRA)-Institut de recherche de l'Ecole de biotechnologie de Strasbourg (IREBS)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Sciences du Vivant [q-bio]/Biochimie
Biologie Moléculaire Biochemistry Epigenesis Genetic 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine In vivo [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry Molecular Biology/Genomics [q-bio.GN] Sciences de l'ingénieur [physics]/Traitement du signal et de l'image Animals Humans Epigenetics Molecular Biology Transcription factor DNA Chromosomes & Chromosomal Structure Review Articles 030304 developmental biology Regulation of gene expression 0303 health sciences DNA methylation Gene Expression & Regulation Computational Biology DNA Genomics 3. Good health Cell biology Gene regulation chemistry TF binding 030217 neurology & neurosurgery Protein Binding Transcription Factors |
| Zdroj: | Essays in Biochemistry Essays in Biochemistry, Portland Press, 2019, 63 (6), pp.727-741. ⟨10.1042/EBC20190033⟩ |
| ISSN: | 0071-1365 |
| DOI: | 10.1042/EBC20190033⟩ |
| Popis: | Dynamic binding of transcription factors (TFs) to regulatory elements controls transcriptional states throughout organism development. Epigenetics modifications, such as DNA methylation mostly within cytosine-guanine dinucleotides (CpGs), have the potential to modulate TF binding to DNA. Although DNA methylation has long been thought to repress TF binding, a more recent model proposes that TF binding can also inhibit DNA methylation. Here, we review the possible scenarios by which DNA methylation and TF binding affect each other. Further in vivo experiments will be required to generalize these models. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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