Treating ectopic pregnancy with the combination of mifepristone and methotrexate: A phase II nonrandomized study
| Autor: | E. Camus, Patrick Rozenberg, François Goffinet, M. Perdu, Henri-Jean Philippe, Claude Chastang, Israel Nisand |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Risk medicine.medical_specialty medicine.medical_treatment Urology Phases of clinical research Chorionic Gonadotropin Pregnancy Oral administration medicine Humans Treatment Failure Abortifacient Chemotherapy Ectopic pregnancy business.industry Abortifacient Agents Steroidal Obstetrics and Gynecology Mifepristone medicine.disease Pregnancy Ectopic Surgery Methotrexate Drug Therapy Combination Female business medicine.drug |
| Zdroj: | American Journal of Obstetrics and Gynecology. 179:640-643 |
| ISSN: | 0002-9378 |
| Popis: | OBJECTIVE: Our goal was to compare the use of a combination of methotrexate and mifepristone with methotrexate alone in the medical management of ectopic pregnancy. STUDY DESIGN: This was a preliminary nonrandomized phase II study. All patients with progressing ectopic pregnancy meeting criteria for medical management were included. Treatment consisted of 50 mg/m 2 of methotrexate injected intramuscularly and 600 mg of mifepristone, administered orally, compared with a previous group who received only 50 mg/m 2 of methotrexate injected intramuscularly. RESULTS: Of the 30 patients treated with the combination, there was only 1 failure, whereas medical treatment had failed for 11 of 42 patients treated with methotrexate alone. CONCLUSIONS: The combination of mifepristone and methotrexate decreased the risk of failure in medical treatment of ectopic pregnancy. (Am J Obstet Gynecol 1998;179:640-3.) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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