Exploiting biospectroscopy as a novel screening tool for cervical cancer: towards a framework to validate its accuracy in a routine clinical setting
Autor: | Maria Kyrgiou, Georgios Theophilou, Júlio Trevisan, Evangelos Paraskevaidis, Pierre L. Martin-Hirsch, Walter Prendiville, Nikhil Purandare, Mary Martin, Günther von Bünau, Alana L. Mitchell, Ketan Gajjar, Imran I. Patel, George Valasoulis, Francis Martin |
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Rok vydání: | 2013 |
Předmět: |
Cervical cancer
medicine.medical_specialty Cervical screening Computer science Clinical Biochemistry Uterine Cervical Neoplasms Clinical settings General Medicine medicine.disease Analytical Chemistry Medical Laboratory Technology medicine Humans Mass Screening Female Medical physics Screening tool Computational analysis General Pharmacology Toxicology and Pharmaceutics Early Detection of Cancer |
Zdroj: | Bioanalysis. 5:2697-2711 |
ISSN: | 1757-6199 1757-6180 |
Popis: | Biospectroscopy is an emerging field that harnesses the platform of physical sciences with computational analysis in order to shed novel insights on biological questions. An area where this approach seems to have potential is in screening or diagnostic clinical settings, where there is an urgent need for new approaches to objectively interrogate large numbers of samples in an objective fashion with acceptable levels of sensitivity and specificity. This review outlines the benefits of biospectroscopy in screening for precancer lesions of the cervix due to its ability to separate different grades of dysplasia. It evaluates the feasibility of introducing this technique into cervical screening programs on the basis of its ability to identify biomarkers of progression within derived spectra (‘biochemical‑cell fingerprints’). |
Databáze: | OpenAIRE |
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