A concise and scalable strategy for the total synthesis of dictyodendrin B based on sequential C-H functionalization
| Autor: | Robert H. Snell, Matthew J. Gaunt, Fionn O'Hara, Andrew K. Pitts |
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| Přispěvatelé: | Gaunt, Matthew [0000-0002-7214-608X], Apollo - University of Cambridge Repository |
| Rok vydání: | 2015 |
| Předmět: |
Natural product
metal catalysis Indoles CH functionalization Molecular Structure flow chemistry natural products Carbazoles Total synthesis Hydrogen Bonding General Chemistry Flow chemistry General Medicine Chemistry Techniques Synthetic Combinatorial chemistry Catalysis Dictyodendrin B chemistry.chemical_compound chemistry Surface modification Organic chemistry Pyrroles total synthesis |
| Zdroj: | Angewandte Chemie (International ed. in English). 54(18) |
| ISSN: | 1521-3773 |
| Popis: | A sequential CH functionalization strategy for the synthesis of the marine alkaloid dictyodendrin B is reported. Our synthesis begins from commercially available 4-bromoindole and involves six direct functionalizations around the heteroarene core as part of a gram-scale strategy towards the natural product. |
| Databáze: | OpenAIRE |
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