Mohs Micrographic Surgery for the Treatment of Merkel Cell Carcinoma
| Autor: | Brett M. Coldiron, Laura Kline |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Skin Neoplasms medicine.medical_treatment Dermatology Metastasis 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine medicine Mohs surgery Carcinoma Humans Aged Retrospective Studies Aged 80 and over Chemotherapy business.industry Merkel cell carcinoma General surgery Wide local excision Retrospective cohort study Extremities General Medicine medicine.disease Mohs Surgery Radiation therapy Carcinoma Merkel Cell Chemotherapy Adjuvant Head and Neck Neoplasms 030220 oncology & carcinogenesis Lymphatic Metastasis Surgery Female Radiotherapy Adjuvant Neoplasm Recurrence Local business |
| Zdroj: | Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. 42(8) |
| ISSN: | 1524-4725 |
| Popis: | Background Merkel cell carcinoma (MCC) is a rare, aggressive malignant neoplasm. Traditionally, wide local excision has been used for local control. However, the tissue-sparing capability of Mohs micrographic surgery (MMS) and the greater certainty of complete tumor removal offer a potential advantage over wide local excision if MMS offers acceptable cure rates. Objective This study aims to help elucidate management of MCC and includes one of the largest groups of patients from a single institution. Materials and methods This study is a retrospective chart review of 22 patients with cutaneous MCC treated with MMS at our practice over 20 years. Clinical characteristics and outcomes were examined. The study protocol conformed to the ethical guidelines of the 1975 Declaration of Helsinki as reflected in the approval by our institution's human research review committee. Results The overall local recurrence rate was 5% (1/22). The overall rate of biopsy-proven metastasis to regional lymph nodes was 14% (3/22). No cases of distant metastases were documented. Conclusion To our knowledge, this is the largest group of patients with MCC treated with MMS from a single institution and indicates that MMS may be a useful treatment modality for this rare aggressive disease. |
| Databáze: | OpenAIRE |
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