Positive Association Between Neutrophil-Lymphocyte Ratio and Presence of Panoramically Imaged Carotid Atheromas Among Men
| Autor: | Arthur H. Friedlander, Hoang-Anh Tran, Robert S. Redman, Urie K. Lee, Tina I. Chang, John C. Polanco |
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| Rok vydání: | 2018 |
| Předmět: |
Carotid Artery Diseases
Male medicine.medical_specialty Neutrophils Systemic inflammation Logistic regression 03 medical and health sciences 0302 clinical medicine Risk Factors Diabetes mellitus Internal medicine Hyperlipidemia Radiography Panoramic medicine Humans Lymphocytes Stroke Aged Retrospective Studies medicine.diagnostic_test business.industry fungi 030206 dentistry Middle Aged medicine.disease Confidence interval Plaque Atherosclerotic medicine.anatomical_structure Cross-Sectional Studies Otorhinolaryngology 030220 oncology & carcinogenesis Angiography Cardiology Surgery Oral Surgery medicine.symptom business Artery |
| Zdroj: | Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons. 77(2) |
| ISSN: | 1531-5053 |
| Popis: | Purpose Heightened levels of systemic inflammation documented by increased neutrophil-to-lymphocyte ratios (NLRs) characterize a robust atherosclerosis processes evidenced by carotid and coronary artery plaques at ultrasound and angiography with associated strokes and myocardial infarctions (MIs). Therefore, this study investigated whether calcified carotid artery plaques (CCAPs) on panoramic images (PIs), known to herald future stroke and MI, are associated with increased NLRs. Materials and Methods Using a cross-sectional study design, electronic medical records and PIs of non-Hispanic white men at least 55 years old who were treated by the dental service (January 1, 2017 to December 31, 2017) were retrieved. Two groups of patients (n = 50 per group) with plaque (CCAP+) and without plaque (CCAP−) were constituted. The predictor variable was CCAP+ and the outcome variable was the NLR. A t test analyzed the differences in mean NLRs between groups. Other variables of interest, that is, atherogenic risk factors (hypertension, hyperlipidemia, and diabetes mellitus), were included in a logistic regression analysis to assess their influence on the association of CCAP with the NLR. Significance was set at .05 for all tests. Results The study group of 50 men with CCAP+ (mean age, 71.7 ± 7.47 yr) evidenced a mean NLR of 3.07 ± 1.43. The control group of 50 men with CCAP− (mean age, 69.8 ± 9.29 yr) evidenced a mean NLR of 2.13 ± 0.68. A t test analysis comparison showed a significant (P = .00007) difference (95% confidence interval, 0.49-1.39). Logistic regression failed to show any relevant relation of the NLR with the covariate and other variables of interest. Conclusion There is a strong association between CCAP+ in older non-Hispanic white men and extent of systemic inflammation as evidenced by increased NLRs. These plaques are “risk factors or indicators” for future stroke and MI. Therefore, maxillofacial surgeons providing care for patients with CCAP+ should consider referring them for a comprehensive cerebrovascular and cardiovascular workup. |
| Databáze: | OpenAIRE |
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