Differential expression and interaction of melatonin and thyroid hormone receptors with estrogen receptor α improve ovarian functions in letrozole-induced rat polycystic ovary syndrome

Autor: Gregory M. Brown, Hindole Ghosh, Dilshad Manzar, Daniel P. Cardinali, Seema Rai, Russel J. Reiter, Seithikurippu R. Pandi-Perumal
Jazyk: Spanish; Castilian
Rok vydání: 2022
Předmět:
HIPOTIROIDISMO
endocrine system
medicine.medical_specialty
Thyroid Hormones
endocrine system diseases
Thyroid Gland
Estrogen receptor
DIO2
Gene Expression
HORMONAS TIROIDEAS
Hyperthyroidism
General Biochemistry
Genetics and Molecular Biology
Melatonin
Internal medicine
medicine
Animals
MELATONINA
Testosterone
General Pharmacology
Toxicology and Pharmaceutics
Rats
Wistar
Triiodothyronine
Thyroid hormone receptor
Receptors
Thyroid Hormone
business.industry
Thyroid
Ovary
Estrogen Receptor alpha
General Medicine
Polycystic ovary
GLANDULA TIROIDES
Rats
Disease Models
Animal
Thyroxine
medicine.anatomical_structure
Endocrinology
Gene Expression Regulation
OVARIOS
Letrozole
Female
HIPERTIROIDISMO
business
hormones
hormone substitutes
and hormone antagonists
Gonadotropins
medicine.drug
Hormone
Polycystic Ovary Syndrome
Zdroj: Life Sciences. 2022, 295
Repositorio Institucional (UCA)
Pontificia Universidad Católica Argentina
instacron:UCA
Popis: Fil: Ghosh, Hindole. Kalinga University. Department of Zoology; India Fil: Rai, Seema. Guru Ghasidas Vishwavidyalaya. Department of Zoology; India Fil: Manzar, Md Dilshad. Majmaah University. College of Applied Medical Sciences. Department of Nursing; Arabia Saudita Fil: Pandi Perumal, Seithikurippu R. Saveetha University. Saveetha Institute of Medical and Technical Sciences. Saveetha Medical College and Hospitals; India Fil: Brown, Gregory M. University of Toronto. Centre for Addiction and Mental Health. Department of Psychiatry; Canada Fil: Reiter, Russel J. University of Texas. Health Science Center at San Antonio. Department of Cell Systems and Anatomy, Estados Unidos Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina Abstract: The objective of the present study was to investigate the effect of melatonin and L-thyroxine (T4) on the expression of various receptors, and some metabolic, reproductive, and gonadotropic hormones in letrozole-induced polycystic ovary syndrome (PCOS) in rats. - Material and methods: Assessment of gravimetric, hormonal profile and thyroid histology and relative expression of melatonin receptors (MT1, MT2) and estrogen receptor α (Erα) in thyroid and ovary, and type II iodothyronine deiodinase (Dio2) and thyroid hormone receptor α (TRα) in the ovary were performed using standard protocols. - Key findings: A significant increase in thyroid follicles numbers was noted in the hyperthyroid rat. T4 treatment to PCOS showed the expected increment in the circulating level of triiodothyronine (T3) and T4. Melatonin and T4 treatment of PCOS rats resulted in a significant decrease in the circulating level of T3 and T4. Hyperthyroid rats showed a decrement in plasma melatonin levels. However, T4 treatment to PCOS rats showed increased circulating melatonin levels, and a decrease in the circulating level of gonadotropins (LH and FSH), and testosterone. Melatonin treatment to PCOS-hyperthyroid rats resulted in the normal expression of ovarian and thyroid MT1 and ERα, receptors, which had been altered in PCOS and hyperthyroid rats, without any significant change in the MT2 receptor. - Significance: The present findings suggest a fine interplay and cross-talk via melatonin and its two receptors with ERα, TRα, and Dio2in thyroid and ovarian tissue during PCOS and hyperthyroidism pathogenicity.
Databáze: OpenAIRE
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