Lipid metabolites as regulators of airway smooth muscle function
| Autor: | Deborah L. Clarke, Jane E. Ward, Shyamala Dakshinamurti, Akira Yamasaki, Anna Larsson |
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| Rok vydání: | 2009 |
| Předmět: |
Pulmonary and Respiratory Medicine
Isoprostane medicine.medical_treatment Respiratory System Bronchi Inflammation Biology Extracellular matrix chemistry.chemical_compound medicine Animals Humans Pharmacology (medical) Receptor Leukotriene Biochemistry (medical) Muscle Smooth Lipid signaling respiratory system Isoprostanes respiratory tract diseases Cytokine Models Chemical chemistry Immunology Eicosanoids lipids (amino acids peptides and proteins) Lysophospholipids medicine.symptom Muscle Contraction |
| Zdroj: | Pulmonary Pharmacology & Therapeutics. 22:426-435 |
| ISSN: | 1094-5539 |
| DOI: | 10.1016/j.pupt.2008.12.003 |
| Popis: | Compelling evidence identifies airway smooth muscle (ASM) not only as a target but also a cellular source for a diverse range of mediators underlying the processes of airway narrowing and airway hyperresponsiveness in diseases such as asthma. These include the growing family of plasma membrane phospholipid-derived polyunsaturated fatty acids broadly characterised by the prostaglandins, leukotrienes, lipoxins, isoprostanes and lysophospholipids. In this review, we describe the enzymatic and non-enzymatic biosynthetic pathways of these lipid mediators and how these are influenced by drug treatment, oxidative stress and airways disease. Additionally, we outline their cognate receptors, many of which are expressed by ASM. We describe potential deleterious and protective roles for these lipid mediators in airway inflammatory and remodelling processes by describing their effects on diverse functions of ASM in asthma that have the potential to contribute to asthma pathogenesis and symptoms. These functions include contractile tone development, cytokine and extracellular matrix production, and cellular proliferation and migration. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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