Pycnogenol accelerates wound healing and reduces scar formation
| Autor: | M Gábor, Gábor Blazsó, Peter Rohdewald, F. Schönlau |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
Scars Healing time Pharmacology Rats sprague dawley law.invention Rats Sprague-Dawley law medicine Animals Humans Flavonoids Wound Healing Dose-Response Relationship Drug business.industry Plant Extracts Pinus Surgery Rats Sprague dawley Pinus Female medicine.symptom Wound healing Phytotherapy business |
| Zdroj: | Phytotherapy research : PTR. 18(7) |
| ISSN: | 0951-418X |
| Popis: | Pycnogenol was applied topically to experimental wounds inflicted on healthy rats by means of a branding iron. The wound-healing time was taken as the number of days required for 50% of the scabs to separate spontaneously from the animals. Application of a gel formulation containing 1% Pycnogenol significantly shortened the wound healing time, by 1.6 days compared with the group treated with gel only (15.4 days). The application of 2% Pycnogenol decreased the healing time by almost 3 days, while 5% Pycnogenol further accelerated the wound-healing process. In parallel, Pycnogenol gels reduced the diameter of the scars remaining following complete scab loss in a concentration-dependent manner. In conclusion, Pycnogenol is a potent active ingredient for the treatment of minor injuries. |
| Databáze: | OpenAIRE |
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