Association between Fetal MTHFR A1298C (rs1801131) Polymorphism and Neural Tube Defects Risk: A Systematic Review and Meta-Analysis
| Autor: | Sara Soleimani-Jadidi, Amaneh Hadadan, Hajar Abbasi, Seyed Reza Mirjalili, Reza Bahrami, Bahare Meibodi, Razieh Sadat Tabatabaei, Atiyeh Javaheri, Leila Zanbagh, Mojgan Karimi-Zarchi, Hossein Neamatzadeh |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
congenital
hereditary and neonatal diseases and abnormalities Genotype Bioinformatics Polymorphism Single Nucleotide Pathology and Forensic Medicine Stratified analysis Fetus Pregnancy medicine Humans Mthfr c677t Genetic Predisposition to Disease Pooled data Neural Tube Defects Methylenetetrahydrofolate Reductase (NADPH2) Polymorphism Genetic biology Spina bifida business.industry Neural tube Prenatal Care General Medicine medicine.disease digestive system diseases medicine.anatomical_structure Case-Control Studies Meta-analysis Methylenetetrahydrofolate reductase Pediatrics Perinatology and Child Health biology.protein Female business |
| Zdroj: | Fetal and Pediatric Pathology. 41:116-133 |
| ISSN: | 1551-3823 1551-3815 |
| DOI: | 10.1080/15513815.2020.1764682 |
| Popis: | Background: The association of the fetal MTHFR A1298C (rs1801131) polymorphism and neural tube defects (NTDs) susceptibility has been widely demonstrated, but the results remain inconclusive. Thus, we performed a meta-analysis to investigate the association between fetal MTHFR A1298C polymorphism and NTDs risk.Methods: An electronic search of PubMed, web of science, SciELO, CNKI database for studies on the fetal MTHFR A1298C polymorphism and NTDs risk was performed up to March 30, 2020.Results: A total of 22 case-control studies with 3,224 fetuses with NTDs and 3,295 controls were selected. Overall, pooled data showed that the fetal MTHFR A1298C polymorphism was not significantly associated with risk an increased risk of NTDs in the global population. When stratified analysis by ethnicity, country of origin and NTDs type, still no statistically significant association was found.Conclusions: Our pooled data emerged no evidence for significant association between fetal MTHFR A1298C polymorphism and NTDs risk. |
| Databáze: | OpenAIRE |
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