Effects of indole fatty alcohols on the differentiation of neural stem cell derived neurospheres
| Autor: | Marie Paschaki, Julien Bouissac, Djalil Coowar, Eliane Mohier, Mazen Hanbali, Bang Luu |
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| Rok vydání: | 2004 |
| Předmět: |
Indoles
Free Radicals Transcription Genetic Notch signaling pathway Fatty alcohol Receptors Cell Surface In Vitro Techniques chemistry.chemical_compound Mice Structure-Activity Relationship Precursor cell Neurosphere Proto-Oncogene Proteins Drug Discovery Animals Benzothiazoles Receptor Notch2 Receptor Notch1 Receptor Receptor Notch4 Indole test Neurons Receptors Notch Chemistry Reverse Transcriptase Polymerase Chain Reaction Stem Cells Membrane Proteins Cell Differentiation Free Radical Scavengers Oligonucleotides Antisense Neural stem cell Cell biology Biochemistry Alcohols Molecular Medicine Stem cell Fatty Alcohols Sulfonic Acids Transcription Factors |
| Zdroj: | Journal of medicinal chemistry. 47(25) |
| ISSN: | 0022-2623 |
| Popis: | In a search for inducers of neuronal differentiation to treat neurodegenerative diseases such as Alzheimer's disease, a series of indole fatty alcohols (IFAs) were prepared. 13c (n = 18) was able to promote the differentiation of neural stem cell derived neurospheres into neurons at a concentration of 10 nM. Analysis of the expression of the Notch pathway genes in neurospheres treated during the differentiation phase with 13c (n = 18) revealed a significant decrease in the transcription of the Notch 4 receptor. |
| Databáze: | OpenAIRE |
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