Investigation ofTurnera ulmifoliaeffects in pregnant rats and offspring
| Autor: | Luiz Alberto Lira Soares, Valéria Cristina Ribeiro Dantas, José Brandão Neto, Maria das Graças Almeida, Tatiane Pereira de Souza, Aline Schwarz, Luana Janine Lopes da Costa |
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| Rok vydání: | 2009 |
| Předmět: |
Pharmacology
education.field_of_study Pregnancy Traditional medicine biology Offspring business.industry Population Pharmaceutical Science Gestation period General Medicine biology.organism_classification medicine.disease Turnera ulmifolia Turneraceae Complementary and alternative medicine Drug Discovery medicine Gestation Molecular Medicine medicine.symptom education business Weight gain |
| Zdroj: | Pharmaceutical Biology. :090820023730090-7 |
| ISSN: | 1744-5116 1388-0209 |
| DOI: | 10.1080/13880200902995533 |
| Popis: | Turnera ulmifolia Linn. (Turneraceae) is an herb commonly found in northeastern Brazil, frequently employed in folk medicine, including by pregnant woman, for many afflictions due to it expectorant, tonic, anti-inflammatory, antiulcerogenic, and antioxidant effects. This work studied the infusion commonly used by the population, obtained by maceration of fresh leaves of T. ulmifolia in filtered water, to evaluate if the same may promote alterations in rat gestation and exposed offspring. Pregnant rats received, by gavage, the aqueous extract (0, 1, 2, or 3 g/kg/day) from gestation day (GD) 1 to GD 21. The treatment was not able to promote maternal toxicity: body weight gain, food and water intake were not altered during gestation period. The offspring presented normal physical and reflexological development. No alterations were observed in the histopathological study and sexual hormone levels of the dams and offspring at 30, 60, and 90 days of age. The sexual behavior was evaluated in male and female offs... |
| Databáze: | OpenAIRE |
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