Microfluidic Formation of Monodisperse Coacervate Organelles in Liposomes
| Autor: | Wilhelm T. S. Huck, Nan-Nan Deng |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Protocell
liposomes Microfluidics Dispersity microfluidics Nanotechnology artificial organelles 02 engineering and technology 010402 general chemistry 01 natural sciences Catalysis Organelle Particle Size Unilamellar Liposomes coacervates Organelles Liposome Coacervate Artificial cell Chemistry 010405 organic chemistry Communication General Chemistry General Medicine Artificial Cell Models Microfluidic Analytical Techniques 021001 nanoscience & nanotechnology Communications 0104 chemical sciences phase transitions 0210 nano-technology Physical Organic Chemistry Artificial Organelles |
| Zdroj: | Angewandte Chemie (International Ed. in English) Angewandte Chemie. International Edition, 56, 33, pp. 9736-9740 Angewandte Chemie. International Edition, 56, 9736-9740 Angewandte Chemie International Edition |
| ISSN: | 1521-3773 1433-7851 |
| Popis: | Coacervates have been widely studied as model compartments in protocell research. Complex coacervates composed of disordered proteins and RNA have also been shown to play an important role in cellular processes. Herein, we report on a microfluidic strategy for constructing monodisperse coacervate droplets encapsulated within uniform unilamellar liposomes. These structures represent a bottom‐up approach to hierarchically structured protocells, as demonstrated by storage and release of DNA from the encapsulated coacervates as well as localized transcription. |
| Databáze: | OpenAIRE |
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