Experimental Autoimmune Meningitis: A Novel Neurological Disease in CD28-Deficient Mice
| Autor: | S A Zekavat, S M Phillips, Ehud Lavi, P J Perrin, Catherine A. Rumbley |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
CD4-Positive T-Lymphocytes
Male Pathology medicine.medical_specialty Encephalomyelitis Autoimmune Experimental Molecular Sequence Data Immunology chemical and pharmacologic phenomena medicine.disease_cause Autoantigens Autoimmune Diseases Autoimmunity Myelin oligodendrocyte glycoprotein Pathogenesis Mice Immune system CD28 Antigens medicine Animals Immunology and Allergy Amino Acid Sequence Meningitis Aseptic Mice Knockout biology business.industry Multiple sclerosis Experimental autoimmune encephalomyelitis Aseptic meningitis hemic and immune systems medicine.disease Mice Inbred C57BL Disease Models Animal Myelin-Associated Glycoprotein biology.protein Female Immunization Myelin-Oligodendrocyte Glycoprotein Chemokines business Meningitis Myelin Proteins Granulocytes |
| Zdroj: | Clinical Immunology. 91:41-49 |
| ISSN: | 1521-6616 |
| Popis: | C57BL/6 mice develop T-cell-mediated experimental autoimmune encephalomyelitis (EAE) after immunization with the neuroantigen myelin oligodendrocyte glycoprotein. (MOG). We immunized CD28-deficient C57BL/6 mice to determine the role of T cell costimulation in the immune response to MOG. CD28−/−mice developed experimental autoimmune meningitis (EAM). EAM is a fatal, acute disease characterized by simultaneous weakness in all limbs, photophobia, irritability, and spatial disorientation. Histologically, EAM consisted of an infiltrate of myeloid, monocytic, and lymphocytic leukocytes within the leptomeninges. In contrast, the brain parenchyma was unaffected. EAM was mediated by CD4+T cells since CD4 depletion prevented the disease. Upon rechallenge, mice in which EAM was prevented by CD4+cell depletion developed EAE not EAM. Therefore, the presence or absence of CD28 determines the initial phenotype of the immune response to MOG. EAM, which develops in the absence of CD28, is a unique experimental model for immune-mediated aseptic meningitis. |
| Databáze: | OpenAIRE |
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