Influence of temperature on thromboelastometry and platelet aggregation in cardiac arrest patients undergoing targeted temperature management
| Autor: | Anne-Mette Hvas, Anni Nørgaard Jeppesen, Hans Kirkegaard, Susanne Ilkjær |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Platelet Aggregation medicine.medical_treatment Hypothermia 030204 cardiovascular system & hematology Targeted temperature management Critical Care and Intensive Care Medicine 03 medical and health sciences 0302 clinical medicine Hypothermia Induced Internal medicine Antithrombotic medicine Coagulation testing Humans Blood Coagulation Aged Whole blood Platelet function test Coagulation medicine.diagnostic_test business.industry Research Thromboelastometry Temperature Disease Management 030208 emergency & critical care medicine Heart arrest Middle Aged Thromboelastography Thrombelastography Surgery Clotting time Cardiology Female medicine.symptom business Out-of-Hospital Cardiac Arrest Haemostasis |
| Zdroj: | Jeppesen, A N, Kirkegaard, H, Ilkjær, S & Hvas, A M 2016, ' Influence of temperature on thromboelastometry and platelet aggregation in cardiac arrest patients undergoing targeted temperature management ', Critical Care (Online Edition), vol. 20, no. 1, pp. 118 . https://doi.org/10.1186/s13054-016-1302-9 Critical Care |
| DOI: | 10.1186/s13054-016-1302-9 |
| Popis: | BACKGROUND: Coagulation can be visualised using whole blood coagulation analyses such as thromboelastometry and platelet aggregation tests; however, the role of temperature in the analyses is ambiguous. The aim was to examine whether temperature influences the whole blood coagulation tests.METHODS: We included 40 patients treated with targeted temperature management (33 ± 1 °C) after out-of-hospital cardiac arrest. The blood samples were obtained on hypothermia and normothermia. Each blood sample was analysed simultaneously at 33 °C and 37 °C by thromboelastography (ROTEM®) employing the assays EXTEM®, INTEM®, FIBTEM® and HEPTEM®, and by Multiplate®Analyzer, using COLtest®, ADPtest®, ASPItest® and TRAPtest® as agonists. Data on antithrombotic drugs were collected systematically from medical records, and data were analysed using repeated measurement analysis of variance (ANOVA).RESULTS: The ROTEM® analyses showed increased clotting time, lower maximum velocity and increased time to maximum velocity (all p values 0.09) analysed at 33 °C and 37 °C, independent of the body temperature. In the hypothermic blood sample, no difference was found when using the COLtest®, ASPItest® or TRAPtest® to compare platelet aggregation analysed at 33 °C and 37 °C (all p values >0.19), but platelet aggregation was significantly higher using the ADPtest® (p CONCLUSION: ROTEM® analyses seemed not to be dependent on body temperature but showed a slower initiation of coagulation when analysed at 33 °C compared with 37 °C. The Multiplate®Analyzer results were dependent on the temperature used in the analyses and the body temperature. In whole blood coagulation tests, the temperature used in the analyses should be kept at 37 °C irrespective of the patient's body temperature being 33 °C or 37 °C. |
| Databáze: | OpenAIRE |
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