Bacterial-Derived Polymer Poly-y-Glutamic Acid (y-PGA)-Based Micro/Nanoparticles as a Delivery System for Antimicrobials and Other Biomedical Applications

Autor: Marek Kowalczuk, Iza Radecka, Ibrahim R Khalil, Alan T. H. Burns, Tamara Khalaf, Brian H. Johnston, Grazyna Adamus, Martin Khechara
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Nanoparticle
Review
02 engineering and technology
lcsh:Chemistry
Drug Delivery Systems
Anti-Infective Agents
Coated Materials
Biocompatible
drug delivery system
Solubility
lcsh:QH301-705.5
Spectroscopy
chemistry.chemical_classification
Drug Carriers
Vaccines
Chemistry
Gene Transfer Techniques
General Medicine
Polymer
021001 nanoscience & nanotechnology
Antimicrobial
Computer Science Applications
Polyglutamic Acid
Drug delivery
0210 nano-technology
Biocompatibility
γ-PGA
Drug Compounding
Antineoplastic Agents
Nanotechnology
engineering.material
Catalysis
Inorganic Chemistry
03 medical and health sciences
Animals
Humans
Hypoglycemic Agents
Physical and Theoretical Chemistry
Molecular Biology
Bacteria
Organic Chemistry
030104 developmental biology
lcsh:Biology (General)
lcsh:QD1-999
Solvents
engineering
Nanoparticles
antimicrobial
Biopolymer
Conjugate
Zdroj: International Journal of Molecular Sciences, Vol 18, Iss 2, p 313 (2017)
International Journal of Molecular Sciences
ISSN: 1422-0067
Popis: In the past decade, poly-γ-glutamic acid (γ-PGA)-based micro/nanoparticles have garnered remarkable attention as antimicrobial agents and for drug delivery, owing to their controlled and sustained-release properties, low toxicity, as well as biocompatibility with tissue and cells. γ-PGA is a naturally occurring biopolymer produced by several gram-positive bacteria that, due to its biodegradable, non-toxic and non-immunogenic properties, has been used successfully in the medical, food and wastewater industries. Moreover, its carboxylic group on the side chains can offer an attachment point to conjugate antimicrobial and various therapeutic agents, or to chemically modify the solubility of the biopolymer. The unique characteristics of γ-PGA have a promising future for medical and pharmaceutical applications. In the present review, the structure, properties and micro/nanoparticle preparation methods of γ-PGA and its derivatives are covered. Also, we have highlighted the impact of micro/nanoencapsulation or immobilisation of antimicrobial agents and various disease-related drugs on biodegradable γ-PGA micro/nanoparticles.
Databáze: OpenAIRE
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