Which are the long-term outcomes of prostate cancer patients undergoing non-interventional management (i.e., watchful waiting) and what is the impact of comorbidities and life expectancy? – PIONEER Research Question #2
| Autor: | Giorgio Gandaglia, Katharina Bayer, Kees van Bochove, Anders Bjartell, Alberto Briganti, Phil Conford, Susan Evans Axelsson, Muhammad Imran Omar, James N’Dow, Alex Asiimwe, Monique Roobol, Robert Snijder, Carl Steinbeisser, Peter-Paul Willemse, Roderick Van Den Bergh, Ariel Achtman, Nicolas Thurin, Asieh Golozar, Mieke Van Hemelrijck, Emma Jane Smith |
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| Rok vydání: | 2021 |
| Předmět: |
bepress|Medicine and Health Sciences|Public Health|Clinical Epidemiology
bepress|Medicine and Health Sciences MetaArXiv|Medicine and Health Sciences|Public Health|Clinical Epidemiology MetaArXiv|Medicine and Health Sciences bepress|Medicine and Health Sciences|Public Health MetaArXiv|Medicine and Health Sciences|Public Health |
| Popis: | Watchful waiting (WW) represents a deferred treatment option for prostate cancer (PCa) patients when curative treatment seems overtreatment right from the outset. Patients are ‘watched’ for the development of local or systemic progression with disease-related symptoms, at which stage they are then treated palliatively according to their symptoms, in order to maintain quality of life (QoL). When choosing WW, it is important to adequately assess life expectancy of patients. Although previous studies reported the outcomes of PCa patients managed with WW, their results might not be generalizable to contemporary patients. Moreover, which is the impact of individual patient characteristics and comorbidities on long-term outcomes is still largely unknown. In the face of such a paucity of data, the PIONEER, which is a novel project of the Innovative Medicine Initiative’s (IMI’s) “Big Data for Better Outcomes” program with the mission to transform PCa care with particular focus on improving cancer-related outcomes, health system efficiency and the quality of health and social care across Europe, aims at assessing which are the long-term outcomes of PCa patients undergoing WW overall and after stratification according to disease characteristics, comorbidities and life expectancy. Of note, this question emerged as the second one with the highest agreement score among different stakeholders after an international consensus to identify and prioritize the most important questions in the field of PCa performed within the PIONEER project. |
| Databáze: | OpenAIRE |
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