Ethanol extract ofCotinus coggygrialeaves accelerates wound healing process in diabetic rats

Autor: Fikret Izzettin, Fikriye Uras, Halil Aksoy, Leyla Bitis, Dilek Akakin, Ali Şen, Mesut Sancar, Turgut Şekerler, Şükran Kültür
Přispěvatelé: Aksoy, Halil, Sen, Ali, Sancar, Mesut, Sekerler, Turgut, Akakin, Dilek, Bitis, Leyla, Uras, Fikriye, Kultur, Sukran, Izzettin, Fikret Vehbi, İZZETTİN, FIKRET VEHBI
Rok vydání: 2016
Předmět:
Zdroj: Pharmaceutical Biology. 54:2732-2736
ISSN: 1744-5116
1388-0209
DOI: 10.1080/13880209.2016.1181660
Popis: Context:Cotinus coggygria Scop. (Anacardiaceae) leaves that were used as wound healing in traditional Balkan and Anatolian folk medicine, could be potentially effective in treating diabetic wounds.Objective: This study investigates biochemical and histological effects of ethanol extract of C. coggygria (CCE) on excision wound model in diabetic rats.Materials and methods: This study was conducted on diabetic Wistar albino rats, which were injected by a single dose (50mg/kg i.p.) streptozotocin. Afterward an excision wound model was created in all animals; diabetic control rats were applied topically simple ointment and diabetic treatment rats were applied topically 5% (w/w) ointment with CC, once a day during the experimental period. Malondialdehyde, glutathione and hydroxyproline levels in wound tissues were investigated at the end of 3rd, 7th, and 14th days. Histopathological examination was also performed.Results: Hydroxyproline content was significantly increased in the CCE treated group versus control after the 3rd and 7th days (15.33 versus 11.83; 19.67 versus 15.67mg/g, p
Databáze: OpenAIRE
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