Single‐Trajectory Multiple‐Target Deep Brain Stimulation for Parkinsonian Mobility and Cognition
| Autor: | Sanskriti Sasikumar, Gavin J B Elias, Alfonso Fasano, Nathan C. Rowland, Andres M. Lozano, Suneil K. Kalia, Alexandre Boutet, Melanie Cohn, Michel Sáenz-Farret, Derrick Soh, Ariana Youm, Sang Soo Cho, Irene E. Harmsen, Katherine Duncan, Aaron Loh, Ricardo Maciel, Jürgen Germann, Antonio P. Strafella |
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| Rok vydání: | 2021 |
| Předmět: |
Deep brain stimulation
Parkinson's disease Deep Brain Stimulation medicine.medical_treatment Stimulation Globus Pallidus Nucleus basalis 03 medical and health sciences Cognition 0302 clinical medicine Humans Medicine 030304 developmental biology 0303 health sciences business.industry Neuropsychology Parkinson Disease medicine.disease 3. Good health Globus pallidus Neurology Dyskinesia Basal Nucleus of Meynert Neurology (clinical) medicine.symptom business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Movement Disorders. 37:635-640 |
| ISSN: | 1531-8257 0885-3185 |
| Popis: | BACKGROUND Deep brain stimulation (DBS) of the nucleus basalis of Meynert (NBM) is an emerging target to potentially treat cognitive dysfunction. OBJECTIVES The aim of this study is to achieve feasibility and safety of globus pallidus pars interna (GPi) and NBM DBS in advanced PD with cognitive impairment. METHODS We performed a phase-II double-blind crossover pilot trial in six participants to assess safety and cognitive measures, the acute effect of NBM stimulation on attention, motor and neuropsychological data at one year, and neuroimaging biomarkers of NBM stimulation. RESULTS NBM DBS was well tolerated but did not improve cognition. GPi DBS improved dyskinesia and motor fluctuations (P = 0.04) at one year. NBM stimulation was associated with reduced right frontal and parietal glucose metabolism (P |
| Databáze: | OpenAIRE |
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