Effect of increased potassium intake on the renin–angiotensin–aldosterone system and subcutaneous resistance arteries: a randomized crossover study
| Autor: | Niels H. Buus, Camilla Asferg, Jørgen Jeppesen, Bahareh Abdolalizadeh, Rasmus Dreier, Julie Lyng Forman, Lisbet Rosenkrantz Hölmich, Martin Egfjord, Majid Sheykhzade, Ulrik B. Andersen |
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| Rok vydání: | 2020 |
| Předmět: |
Transplantation
medicine.medical_specialty Increased urinary potassium Aldosterone business.industry Potassium chemistry.chemical_element 030204 cardiovascular system & hematology Angiotensin II 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Blood pressure Endocrinology chemistry Nephrology Internal medicine Renin–angiotensin system medicine 030212 general & internal medicine Sodium nitroprusside business medicine.drug Myograph |
| Zdroj: | Nephrology Dialysis Transplantation. 36:1282-1291 |
| ISSN: | 1460-2385 0931-0509 |
| Popis: | Background Increased potassium intake lowers blood pressure (BP) in hypertensive patients. The underlying mechanism is not fully understood but must be complex because increased potassium intake elevates circulating concentrations of the BP-raising hormone aldosterone. Methods In a randomized placebo-controlled crossover study in 25 normotensive men, we investigated the effect of 4 weeks of potassium supplement (90 mmol/day) compared with 4 weeks of placebo on the renin–angiotensin–aldosterone system (RAAS), urine composition and 24-h ambulatory BP. Vascular function was also assessed through wire myograph experiments on subcutaneous resistance arteries from gluteal fat biopsies. Results Higher potassium intake increased urinary potassium excretion (144.7 ± 28.7 versus 67.5 ± 25.5 mmol/24-h; P < 0.0001) and plasma concentrations of potassium (4.3 ± 0.2 versus 4.0 ± 0.2 mmol/L; P = 0.0002), renin [16 (12–23) versus 11 (5–16) mIU/L; P = 0.0047], angiotensin II [10.0 (6.2–13.0) versus 6.1 (4.0–10.0) pmol/L, P = 0.0025] and aldosterone [440 (336–521) versus 237 (173–386) pmol/L; P Conclusions Four weeks of increased potassium intake activates the RAAS in normotensive men without changing BP and this is not explained by improved vasodilatory responses ex vivo. |
| Databáze: | OpenAIRE |
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