Ultrafast sub-nanometric spatial accuracy of a fleeting quantum probe interaction with a biomolecule: innovating concept for spatio-temporal radiation biomedicine
| Autor: | Victor Malka, Yann Gauduel |
|---|---|
| Přispěvatelé: | Laboratoire d'optique appliquée (LOA), École Nationale Supérieure de Techniques Avancées (ENSTA Paris)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Ionization
Photon Interdisciplinary fields Electrons Electron law.invention Optics law Nanotechnology Quantum ComputingMilieux_MISCELLANEOUS Cancer Physics [PHYS.PHYS.PHYS-OPTICS]Physics [physics]/Physics [physics]/Optics [physics.optics] Radiation Radiotherapy business.industry Lasers Molecules Laser Chemical species Orders of magnitude (time) Femtosecond Femtosecond lasers [SDV.IB]Life Sciences [q-bio]/Bioengineering business Ultrashort pulse |
| Zdroj: | Conference on Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XI Conference on Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XI, Feb 2014, San Francisco, CA, United States. ⟨10.1117/12.2038983⟩ |
| DOI: | 10.1117/12.2038983⟩ |
| Popis: | During cancer radiotherapy protocols, the early profile of energy deposition is decisive for the prediction and control of radiation-induced biomolecular and sub-cellular damage. A major challenge of spatio-temporal radiation biomedicine, a newly emerging interdisciplinary domain, concerns the complete understanding of biophysical events triggered by an initial energy deposition inside confined ionization clusters (tracks) and evolving over several orders of magnitude, typically from femtosecond (1 fs = 10-15 s) and sub-nanometer scales. The innovating advent of femtosecond laser sources providing ultra-short photon beam and relativistic electron bunches, in the eV and MeV domain respectively, open exciting opportunities for a real-time imaging of radiation-induced biomolecular alterations in nanoscopic tracks. Using a very short-lived quantum probe (2p-like excited electron) and high-time resolved laser spectroscopic methods in the near IR and the temporal window 500 – 5000 fs, we demonstrate that short-range coherent interactions between the quantum probe and a small biosensor of 20 atoms (disulfide molecule) are characterized by an effective reaction radius of 9.6 ± 0.2 angstroms. For the first time, femtobioradical investigations performed with aqueous environments give correlated information on spatial and temporal biomolecular damages triggered by a very short lived quantum scalpel whose the gyration radius is around 6 angstroms. This innovating approach would be applied to more complex biological architectures such as nucleosomes, healthy and tumour cells. In the framework of high-quality ultra-short penetrating radiation beams devoted to pulsed radiotherapy of cancers, this concept would foreshadow the development of real-time nanobiodosimetry combined to highly-selective targeted pro-drug activation. |
| Databáze: | OpenAIRE |
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