| Autor: |
Klaus Zangger, Margarete Focke-Tejkl, Tobias Madl, Josef Thalhamer, Christoph Madritsch, Evelyne Schrank, Nico Tjandra, Sabine Flicker, Simone Kosol, Christoph Göbl, Rudolf Valenta, Nazanin Najafi, Yulia Dorofeeva |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
J. Allergy Clin. Immunol. 140, 1187-1191 (2017) |
| Popis: |
This is the first study determining the three-dimensional structure of Phl p 5a which reveals a novel mechanism for high allergenic activity based on flexibly connected IgE-reactive domains which cross-link effector cell-bound IgE more efficiently than isolated rigid globular proteins. These findings may also form a basis for specific immunotherapy strategies. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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