Glycosphingolipids of human myometrium and endometrium and their changes during the menstrual cycle, pregnancy and ageing
| Autor: | Z. Tsui, Z. Zhu, B. A. Fenderson, H. Deng, E. D. Nudelman |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
Aging Embryology medicine.medical_specialty media_common.quotation_subject Uterus Biology Endometrium Glycosphingolipids Endocrinology Glycolipid Pregnancy Sphingosine Gangliosides Internal medicine Glycosyltransferase medicine G(M3) Ganglioside Humans beta-D-Galactoside alpha 2-6-Sialyltransferase reproductive and urinary physiology Menstrual cycle media_common Globosides urogenital system Infant Newborn Myometrium Obstetrics and Gynecology Cell Biology Middle Aged medicine.disease N-Acetylneuraminic Acid Sialyltransferases Menstruation carbohydrates (lipids) medicine.anatomical_structure Reproductive Medicine Sialic Acids biology.protein Female lipids (amino acids peptides and proteins) Chromatography Thin Layer Hormone |
| Zdroj: | Reproduction. 88:71-79 |
| ISSN: | 1741-7899 1470-1626 |
| DOI: | 10.1530/jrf.0.0880071 |
| Popis: | The glycolipid composition of human myometrium and endometrium was examined at various stages of maturation and reproduction. The major neutral glycolipids of both myometrium and endometrium were identified by high-performance thin-layer chromatography as globo-series glycolipids, Gb3 and Gb4. The major acidic glycolipids (gangliosides) were identified similarly as GM3 and GD3, with lesser amounts of GM1, GD1a, and GT1b. During pregnancy, GD3 expression declined in both myometrium and endometrium, whereas GM3 expression increased. Reciprocal changes in GM3/GD3 expression were mirrored by appropriate changes in the glycosyltransferases required for their synthesis; alpha 2----3sialyltransferase activity increased approximately 3-fold during pregnancy, while alpha 2----8sialyltransferase activity declined to about 20%. The results focus attention on the glycolipids of uterine tissues, their regulation, and their possible role in reproduction and fertility. |
| Databáze: | OpenAIRE |
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