Different inoculum ofLeishmania braziliensisconcentrations influence immunopathogenesis and clinical evolution in the ear dermis hamster model of cutaneous leishmaniasis

Autor:	Rafaelle de Paula Freire, Francisco Rafael Marciano Fonseca, Naya Lúcia Rodrigues de Castro, Carrel Xavier Martins Lima, Raquel Peralva Ribeiro‐Romão, Diane Isabelle Magno Cavalcante, Clarissa Romero Teixeira, Regis Gomes, Alda Maria Da‐Cruz, Maria Jania Teixeira
Rok vydání:	2022
Předmět:	Arginase Mesocricetus Immunology Leishmaniasis Cutaneous Dermis Leishmania braziliensis Interleukin-10 Disease Models Animal Cricetinae Animals Cytokines Humans Parasitology Interleukin-4
Zdroj:	Parasite Immunology. 44
ISSN:	1365-3024 0141-9838
DOI:	10.1111/pim.12947
Popis:	The golden hamster (Mesocricetus auratus) is commonly used as a promising model for Leishmania braziliensis infection developing skin-ulcerated lesions. However, different protocols using high concentration of parasites inoculated in the footpad result in severe clinical disease. Here, we further investigate the outcome of the site of infection and concentration of L. braziliensis parasites inoculated on the immunopathogenesis and clinical evolution. Initially, hamsters were infected in the ear dermis or hind footpad with a concentration of 1 × 10
Databáze:	OpenAIRE
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