Efflux system overexpression and decreased OprD contribute to the carbapenem heterogeneity inPseudomonas aeruginosa
| Autor: | Alexandros Ikonomidis, Athanassios Tsakris, Maria Kantzanou, Spyros Pournaras, Antonios N. Maniatis, Nicholas Spanakis |
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| Rok vydání: | 2008 |
| Předmět: |
Imipenem
Carbapenem Transcription Genetic Mutant Population Gene Expression Porins Microbial Sensitivity Tests Biology medicine.disease_cause Microbiology Meropenem Bacterial Proteins Drug Resistance Bacterial Genetics medicine Humans Pseudomonas Infections education Molecular Biology education.field_of_study Pseudomonas aeruginosa Genetic Variation Membrane Transport Proteins biochemical phenomena metabolism and nutrition biology.organism_classification Anti-Bacterial Agents RNA Bacterial Carbapenems Efflux Bacterial Outer Membrane Proteins medicine.drug Pseudomonadaceae |
| Zdroj: | FEMS Microbiology Letters. 279:36-39 |
| ISSN: | 1574-6968 0378-1097 |
| DOI: | 10.1111/j.1574-6968.2007.00997.x |
| Popis: | Pseudomonas aeruginosa strains exhibiting a heterogeneous mode of growth against carbapenems have been described recently. This study investigated the underlying molecular mechanisms in four genetically unrelated P. aeruginosa clinical isolates that were previously characterized by population analyses as heterogeneously resistant against carbapenems. Mutant subpopulations of all four isolates had at least fourfold higher minimum inhibitory concentrations than those of native cells for imipenem and meropenem. The heterogeneous subpopulations, when compared with the respective native ones, had significantly increased transcription levels of the mexB and mexY genes (P |
| Databáze: | OpenAIRE |
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