Stem cells expand potency and alter tissue fitness by accumulating diverse epigenetic memories

Autor:	Maria Nikolova, Ellen Wong, Matthew T. Tierney, Kevin Andrew Uy Gonzales, Hilda Amalia Pasolli, Shijing Luo, Lisa Polak, Anita Gola, Jesse S S Novak, Nicole R. Infarinato, Siqi Liu, Elaine Fuchs, Irina Matos, Kenneth Lay
Rok vydání:	2021
Předmět:	Inflammation Wound Healing Multidisciplinary Stem Cells Biology Adaptation Physiological Chromatin Cell biology Epigenesis Genetic Mice Immune system Epidermal Cells Cell Movement medicine Potency Animals Homeostasis Regeneration Epigenetics medicine.symptom Stem cell Stem Cell Niche Transcriptome Hair Follicle
Zdroj:	Science (New York, N.Y.). 374(6571)
ISSN:	1095-9203
Popis:	Stem cells remember Tissue stem cells sense their surroundings, and this perception influences subsequent fate and function. Gonzales et al . observed that stem cells accumulate epigenetic memories of diverse environmental events (see the Perspective by Hoste). By wounding skin and monitoring the temporal steps involved in mobilizing stem cells of the hair follicle to repair the epidermis, the authors found that stem cells bear memories of their original niche, migration, encounters with inflammation, and adaptation to the new fate and tasks. During homeostasis, immigrant stem cells are functionally and transcriptionally analogous to native cells, but upon future assaults, they unleash discrete epigenetic memories to heighten physiological response and affect tissue fitness. —BAP
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5989da4427d41771fbea7cfa44ff4362 https://pubmed.ncbi.nlm.nih.gov/34822297 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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