Association of Anorexia Nervosa With Risk of Cancer: A Systematic Review and Meta-analysis
| Autor: | Ferrán Catalá-López, Rafael Tabarés-Seisdedos, Adolfo Alonso-Arroyo, Alfonso Valencia, Eduard Vieta, Jose M Valderas, Matthew J. Page, Manuel Ridao, Diego Macías Saint-Gerons, Jane A. Driver, Ricard Gènova-Maleras, Brian Hutton, Jaume Forés-Martos |
|---|---|
| Přispěvatelé: | Instituto de Salud Carlos III, CIBERSAM, Generalitat Valenciana, US Department of Veterans Affairs, Australian National Health and Medical Research Council, Canadian Institutes of Health Research, Canadian Drug Safety and Effectiveness Network, Red de Investigación en Servicios de Salud en Enfermedades Crónicas (España), Centro de Investigación Biomédica en Red - CIBERSAM (Salud Mental), Generalitat Valenciana (España), United States Department of Veterans Affairs, Ministerio de Ciencia, Innovación y Universidades (España), National Health and Medical Research Council (Australia), Red de Investigación Cooperativa en Investigación en Servicios de Salud en Enfermedades Crónicas |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Anorexia Nervosa Population behavioral disciplines and activities Young Adult 03 medical and health sciences 0302 clinical medicine Breast cancer Neoplasms Internal medicine Observational study mental disorders Humans Medicine 030212 general & internal medicine Sex Distribution Young adult education Original Investigation Aged Cancer education.field_of_study business.industry Research Mortality rate digestive oral and skin physiology General Medicine Middle Aged medicine.disease 3. Good health Online Only Meta-analysis Oncology Anorexia nervosa (differential diagnoses) 030220 oncology & carcinogenesis Systematic review Female Epidemiologic Methods business hormones hormone substitutes and hormone antagonists Cohort study |
| Zdroj: | Repisalud Instituto de Salud Carlos III (ISCIII) JAMA Network Open |
| Popis: | This systematic review and meta-analysis evaluates the association of anorexia nervosa with the cancer incidence and mortality among study populations with anorexia nervosa compared with the general population or those without anorexia nervosa. Key Points Question Are people with anorexia nervosa at a higher risk of developing or dying of cancer compared with those without anorexia and the general population? Findings In this systematic review and meta-analysis of 7 cohort studies including more than 42 000 participants with anorexia nervosa, there was no association of anorexia nervosa with overall cancer incidence or mortality. Anorexia nervosa was inversely associated with breast cancer incidence but positively associated with risk of developing lung and esophageal cancer. Meaning There was no association of anorexia nervosa with risk of cancer overall and few associations of anorexia nervosa with risk of site-specific cancer. Importance Anorexia nervosa is recognized as an important cause of morbidity in young people. However, the risk of cancer in people with anorexia nervosa remains uncertain. Objective To evaluate the association of anorexia nervosa with the risk of developing or dying of cancer. Data Sources MEDLINE, Scopus, Embase, and Web of Science from database inception to January 9, 2019. Study Selection Published observational studies in humans examining the risk of cancer in people with anorexia nervosa compared with the general population or those without anorexia nervosa. Studies needed to report incidence or mortality rate ratios (RRs). Data Extraction and Synthesis Screening, data extraction, and methodological quality assessment were performed by at least 2 researchers independently. A random-effects model was used to synthesize individual studies. Heterogeneity (I2) was assessed and 95% prediction intervals (PIs) were calculated. Main Outcomes and Measures All cancer incidence and cancer mortality associated with anorexia nervosa. Secondary outcomes were site-specific cancer incidence and mortality. Results Seven cohort studies published in 10 articles (42 602 participants with anorexia nervosa) were included. Anorexia nervosa was not associated with risk of developing any cancer (4 studies in women; RR, 0.97; 95% CI, 0.89-1.06; P = .53; I2, 0%; 95% PI, 0.80-1.18; moderate confidence). Anorexia nervosa was associated with decreased breast cancer incidence (5 studies in women; RR, 0.60; 95% CI, 0.50-0.80; P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|