Management of Single Malignant Lung Nodules in Elderly Patients (70 Years or Older) Who are Not Candidates for Lobectomy
| Autor: | Prabhsimranjot Singh, A. Gabriella Wernicke, Dattatreyudu Nori, K. S. Clifford Chao, Samuel Trichter, Stefano Monni, Priti Patel, Bhupesh Parashar, Albert Sabbas |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Lung Neoplasms Radioactive seed Stereotactic body radiation therapy Adenocarcinoma law.invention Iodine Radioisotopes Intraoperative Period Randomized controlled trial law Carcinoma Non-Small-Cell Lung Chart review medicine Humans Statistical analysis In patient Aged Retrospective Studies Lung business.industry Prostheses and Implants Small Cell Lung Carcinoma Sublobar resection Surgery Survival Rate Treatment Outcome medicine.anatomical_structure Oncology Carcinoma Squamous Cell Female business Follow-Up Studies |
| Zdroj: | American Journal of Clinical Oncology. 35:480-485 |
| ISSN: | 0277-3732 |
| Popis: | PURPOSE The aim of this study was to evaluate and compare sublobar resection plus intraoperative seed implant (IOS) versus stereotactic body radiation therapy (SBRT) in patients with single malignant lung nodules in patients 70 years of age or older. MATERIALS AND METHODS A retrospective chart review was performed and 47 patients with adequate information were selected for analysis. Thirty patients with single malignant lung nodules received SBRT. Seventeen patients received limited surgical resection plus radioactive seed implantation for solitary malignant lung nodules. Univariate statistical analysis showed a significant difference only for the age in the 2 groups: the mean age in the radioactive seed group, 78.8 years versus 76.1 years in the SBRT group (2-sided, P=0.05). RESULTS There was high local control and minimal toxicity with either treatment modality and no significant difference among the 2 groups in terms of local control, survival, and toxicity. However, the distant failure was higher but not statistically significant in the SBRT group (9 of 30 patients in SBRT vs. 0 of 17 in IOS, P=0.1). CONCLUSIONS Our study has shown excellent outcomes and limited toxicity in both IOS and SBRT for treatment of single malignant lung nodules in patients who are not candidates for lobectomy. However, a randomized trial is needed in this group of elderly patients to determine the most appropriate treatment. |
| Databáze: | OpenAIRE |
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