EX-MET study: Exercise in prevention on of metabolic syndrome - A randomized multicenter trial: Rational and design
| Autor: | Carlos Roberto Bueno, Erika Ermacora, Jhennyfer Aline Lima Rodrigues, Arnt Erik Tjønna, Ulrik Wisløff, Jeff S. Coombes, Martin Halle, Øyvind Salvesen, Axel Pressler, Peter S. Munk, Klaus Jungbluth, Joyce S. Ramos |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty 030204 cardiovascular system & hematology Interval training law.invention Exercise training Study Protocol 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Multicenter trial Heart rate medicine Humans Stroke business.industry lcsh:Public aspects of medicine Public Health Environmental and Occupational Health lcsh:RA1-1270 030229 sport sciences Guideline Cardiovascular disease medicine.disease Metabolic syndrome Continuous training Exercise Therapy Treatment Outcome RESULTADO DE TRATAMENTO Research Design Physical therapy Female business Follow-Up Studies |
| Zdroj: | BMC Public Health Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP BMC Public Health, Vol 18, Iss 1, Pp 1-7 (2018) |
| Popis: | Background Metabolic syndrome substantially increases risk of cardiovascular events. It is therefore imperative to develop or optimize ways to prevent or attenuate this condition. Exercise training has been long recognized as a corner-stone therapy for reducing individual cardiovascular risk factors constituting the metabolic syndrome. However, the optimal exercise dose and its feasibility in a real world setting has yet to be established. The primary objective of this randomized trial is to investigate the effects of different volumes of aerobic interval training (AIT) compared to the current exercise guideline of moderate-intensity continuous training (MICT) on the composite number of cardiovascular disease risk factors constituting the metabolic syndrome after a 16 week, 1-year, and 3-year follow-up. Methods This is a randomized international multi-center trial including men and women aged ≥30 years diagnosed with the metabolic syndrome according to the International Diabetes Federation criteria. Recruitment began in August 2012 and concluded in December 2016. This trial consists of supervised and unsupervised phases to evaluate the efficacy and feasibility of different exercise doses on the metabolic syndrome in a real world setting. This study aims to include and randomize 465 participants to 3 years of one of the following training groups: i) 3 times/week of 4 × 4 min AIT at 85–95% peak heart rate (HRpeak); ii) 3 times/week of 1 × 4 min AIT at 85–95% HRpeak; or iii) 5–7 times/week of ≥30 min MICT at 60–70% HRpeak. Clinical examinations, physical tests and questionnaires are administered to all participants during all testing time points (baseline, 16 weeks and after 1-, and 3-years). Discussion This multi-center international trial indeed aims to ease the burden in healthcare/economic cost arising from treating end-stage CVD related conditions such as stroke and myocardial infarction, that could eventually emerge from the metabolic syndrome condition. © The Author(s). 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| Databáze: | OpenAIRE |
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