Growth of Human Tumor Xenografts Implanted under the Renal Capsule of Normal Immunocompetent Mice
| Autor: | Doreen J. LePage, Henry J. Esber, William R. Cobb, Arthur E. Bogden, Diane E. Kelton, Paula M. Haskell |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Pathology
medicine.medical_specialty Cyclophosphamide medicine.medical_treatment Transplantation Heterologous Mice Nude Breast Neoplasms Biology Kidney Pathology and Forensic Medicine Mice Renal capsule medicine Animals Humans Neoplasm Molecular Biology Immunosuppression Therapy Capsule Immunosuppression Cell Biology General Medicine medicine.disease Transplantation medicine.anatomical_structure Female Subrenal Capsule Assay Neoplasm Transplantation medicine.drug |
| Zdroj: | Pathobiology. 47:281-293 |
| ISSN: | 1423-0291 1015-2008 |
| DOI: | 10.1159/000162947 |
| Popis: | The subrenal capsule technique proved effective in demonstrating that the growth of human tumors in normal, immunocompetent animals for 6 days was quantifiable in ocular micrometer units. Positive growth was demonstrable not only with human tumors that had been established in serial transplantation in athymic nude mouse hosts, but also with primary surgical explants. Growth rates of transplantation-established xenograft systems were similar whether implanted in athymic nude or in normal immunocompetent animals indicating that the 6-day time-frame successfully evades growth inhibitory effects of immunologic origin. Immunosuppression with a single dose of cyclophosphamide did not appear to affect growth rate, but permitted the tumors to grow larger extending the time to reach peak size. Significantly, xenografts of primary surgical explants showed positive growth more frequently in 6 days (82%) in the immunocompetent animal than in 11 days (30%) in the immunodeficient athymic nude mouse. |
| Databáze: | OpenAIRE |
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