Plasmatic miR-210, miR-221 and miR-1233 profile: Potential liquid biopsies candidates for renal cell carcinoma
| Autor: | Rui Medeiros, Joaquina Maurício, Klaas Kok, Nuno Bastos, Maria Inês Sequeira, Mara Fernandes, Joana Vieira, Bárbara Adem, Marta S. Ferreira, Ana Teixeira, António Morais, Francisco S. N. Lobo, Jorge Oliveira, Francisca Dias |
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| Přispěvatelé: | Guided Treatment in Optimal Selected Cancer Patients (GUTS) |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Modern medicine Pathology renal cell carcinoma Disease prognostic biomarkers Metastasis 03 medical and health sciences 0302 clinical medicine Renal cell carcinoma Internal medicine microRNA medicine circulating miRNAs business.industry Cancer Hypoxia (medical) medicine.disease Circulating MicroRNA 030104 developmental biology 030220 oncology & carcinogenesis medicine.symptom business Research Paper |
| Zdroj: | Oncotarget, 8(61), 103315-103326. Impact Journals LLC Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | Renal cell carcinoma (RCC) represents a challenge for clinicians since the nonexistence of screening and monitoring tests contributes to the fact that one-third of patients are diagnosed with metastatic disease and 20-40% of the remaining patients will also develop metastasis. Modern medicine is now trying to establish circulating biomolecules as the gold standard of biomarkers. Among the molecules that can be released from tumor cells we can find microRNAs. The aim of this study was to evaluate the applicability of cancer-related miR-210, miR-218, miR-221 and miR-1233 as prognostic biomarkers for RCC. Patients with higher levels of miR-210, miR-221 and miR-1233 presented a higher risk of specific death by RCC and a lower cancer-specific survival. The addition of miR-210, miR-221 and miR-1233 plasma levels information improved the capacity to predict death by cancer in 8, 4% when compared to the current variables used by clinicians. We also verified that hypoxia stimulates the release of miR-210 and miR-1233 from HKC-8, RCC-FG2 and 786-O cell lines. These results support the addition of circulating microRNAs as prognostic biomarkers for RCC. |
| Databáze: | OpenAIRE |
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