Complement factor 5 blockade reduces porcine myocardial infarction size and improves immediate cardiac function

Autor: Alice Gustavsen, Robert Rieben, Helge Skulstad, Frédéric Courivaud, Tom Eirik Mollnes, Miles A. Nunn, Anjan K. Bongoni, Alain Despont, Andreas Barratt-Due, Hugues Fontenelle, Helge Scott, Tor Inge Tønnessen, Søren Erik Pischke, Kjetil H. Egge, Hilde Lang Orrem
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Cardiac function curve
medicine.medical_specialty
Physiology
Sus scrofa
Myocardial Infarction
Complement
Infarction
Fluorescent Antibody Technique
Ischemia/reperfusion
Complement factor I
Contractility
Arthropod Proteins
03 medical and health sciences
Complement inhibitor
Random Allocation
Tissue Doppler echocardiography
Internal medicine
Physiology (medical)
medicine
Animals
Myocardial infarction
C5
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771
VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771
Complement component 5
business.industry
VDP::Medical disciplines: 700::Clinical medical disciplines: 750
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750
Complement C5
Original Contribution
medicine.disease
Magnetic Resonance Imaging
3. Good health
Disease Models
Animal
030104 developmental biology
Echocardiography
LTB4
Cardiology
Animal studies
business
Carrier Proteins
Cardiology and Cardiovascular Medicine
Zdroj: 112:20
Basic Research in Cardiology
Pischke, Soeren E; Gustavsen, A; Orrem, H L; Egge, K H; Courivaud, F; Fontenelle, H; Despont, Alain; Bongoni, A K; Rieben, Robert; Tønnessen, T I; Nunn, M A; Scott, H; Skulstad, H; Barratt-Due, A; Mollnes, T E (2017). Complement factor 5 blockade reduces porcine myocardial infarction size and improves immediate cardiac function. Basic research in cardiology, 112(3), p. 20. Springer-Medizin-Verlag 10.1007/s00395-017-0610-9
ISSN: 0300-8428
DOI: 10.1007/s00395-017-0610-9
Popis: Source at: http://doi.org/10.1007/s00395-017-0610-9. Licensed CC BY-NC-ND 4.0. Inhibition of complement factor 5 (C5) reduced myocardial infarction in animal studies, while no benefit was found in clinical studies. Due to lack of cross-reactivity of clinically used C5 antibodies, different inhibitors were used in animal and clinical studies. Coversin (Ornithodoros moubata complement inhibitor, OmCI) blocks C5 cleavage and binds leukotriene B4 in humans and pigs. We hypothesized that inhibition of C5 before reperfusion will decrease infarct size and improve ventricular function in a porcine model of myocardial infarction. In pigs (sus scrofa), the left anterior descending coronary artery was occluded (40 min) and reperfused (240 min). Coversin or placebo was infused 20 min after occlusion and throughout reperfusion in 16 blindly randomized pigs. Coversin significantly reduced myocardial infarction in the area at risk by 39% (p=0.03, triphenyl tetrazolium chloride staining) and by 19% (p=0.02) using magnetic resonance imaging. The methods correlated significantly (R=0.92, p
Databáze: OpenAIRE
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