| Autor: |
Wietfeld Bernhard, Florian Kleinbeck, Jingjing Wu, Liqun Zhao, Francesco Venturoni, Weichun Liu, Xiangguang Tian, Gai Yu, Paolo Filipponi, Thomas Ruch, Nikola Kovacic, Bertrand Guelat, Philippe Piechon, Guanghua Jia, Xi Luo, Junjie Sun, Feng Gao, Xin Gu, Jianghua Zhang, Hai Dong, Thierry Schlama, Nadine Derrien, Thomas Allmendinger, Xiaoquan Lu, Bo Yu, Hongwei Yang, Huijuan Gu, Xuesong Zhang, Huaimin Wang, Yunzhong Li, Pascale Hoehn, Like Chen, Yingtao Tian, Su Xu, Luca Hermann, Berthold Schenkel, Shengqing Ye, Yan Wang, Xingxian Gu, Xufan Wang, Meng Chang, Min Zhongcheng, Jibin Zhao |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
The Journal of organic chemistry. 85(11) |
| ISSN: |
1520-6904 |
| Popis: |
LCZ696 is a novel treatment for patients suffering from heart failure that combines the two active pharmaceutical ingredients sacubitril and valsartan in a single chemical compound. While valsartan is an established drug substance, a new manufacturing process suitable for large-scale commercial production had to be developed for sacubitril. The use of chemocatalysis, biocatalysis, and flow chemistry as state-of-the-art technologies allowed to efficiently build up the structure of sacubitril and achieve the defined performance targets. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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