Peripheral Analgesic Activity

Autor:	Vino Daniel
Rok vydání:	2014
Předmět:	biology business.industry Analgesic Prostaglandin Pharmacology In vitro Peripheral chemistry.chemical_compound chemistry In vivo biology.protein medicine Cyclooxygenase Antipyretic business medicine.drug
Zdroj:	Drug Discovery and Evaluation: Pharmacological Assays ISBN: 9783642277283 Drug Discovery and Evaluation: Pharmacological Assays ISBN: 9783319053912
Popis:	The differentiation between central and peripheral analgesic drugs is nowadays of more or less historical value. Most of the so-called peripheral analgesics possess anti-inflammatory properties and in some cases also antipyretic activity besides analgesia. For many of them, the mode of action has been elucidated as an inhibition of cyclooxygenase in the prostaglandin pathway. Nevertheless, new peripheral analgesics have to be tested not only for their in vitro activity on cyclooxygenase but also for their in vivo activity. The most commonly used methods for measuring peripheral analgesic activity are the writhing tests in mice (various modifications) and the Randall–Selitto test in rats.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5983f69430a6bb85835ce413ac93ba54 https://doi.org/10.1007/978-3-642-27728-3_41-1 Zobrazit plný text záznamu