Kinetics of SARS-CoV-2 Specific and Neutralizing Antibodies over Seven Months after Symptom Onset in COVID-19 Patients
| Autor: | Ming Wu, Yuqing Ding, Changjun Bao, Jiefu Peng, Fengcai Zhu, Jianguang Fu, Xin Xu, Xiaoxiao Kong, Ke Xu, Xin Zou, Hongbin Shen, Baoli Zhu, Huiyan Yu, Haodi Huang, Ci Song, Zhibin Hu, Liguo Zhu, Xiling Guo |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Microbiology (medical) medicine.medical_specialty Adolescent Physiology Antibodies Viral Microbiology Gastroenterology immune response Immunoglobulin G Serology Young Adult Interquartile range Internal medicine Genetics medicine Humans antibodies Young adult Child Neutralizing antibody virus dynamics General Immunology and Microbiology Ecology biology SARS-CoV-2 business.industry COVID-19 Cell Biology Middle Aged Antibodies Neutralizing natural infection QR1-502 Titer Infectious Diseases Immunoglobulin M biology.protein Female Antibody business Immunologic Memory Research Article |
| Zdroj: | Microbiology Spectrum Microbiology Spectrum, Vol 9, Iss 2 (2021) |
| ISSN: | 2165-0497 |
| Popis: | To assess the persistence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies produced by natural infection and describe the serological characteristics over 7 months after symptom onset among coronavirus disease 2019 (COVID-19) patients by age and severity group, we followed up COVID-19 convalescent patients confirmed from 1 January to 20 March 2020 in Jiangsu, China and collected serum samples for testing IgM/IgG and neutralizing antibodies against SARS-CoV-2 between 26 August and 28 October 2020. In total, 284 recovered participants with COVID-19 were enrolled in our study. Patients had a mean age of 46.72 years (standard deviation [SD], 17.09), and 138 (48.59%) were male. The median follow-up time after symptom onset was 225.5 (interquartile range [IQR], 219 to 232) days. During the follow-up period (162 to 282 days after symptom onset), the seropositive rate of IgM fluctuated around 25.70% (95% confidence interval [CI], 20.72% to 31.20%) and that of IgG fluctuated around 79.93% (95% CI, 74.79% to 84.43%). Of the 284 patients, 64 participants were tested when discharged from hospital. Compared with that at the acute phase, the IgM/IgG antibody levels and IgM seropositivity have decreased; however, the seropositivity of IgG was not significantly lower at this follow-up (78.13% versus 82.81%). Fifty percent inhibitory dilution (ID50) titers of neutralizing antibody for samples when discharged from hospital (geometric mean titer [GMT], 82; 95% CI, 56 to 121) were significantly higher than those at 6 to 7 months after discharge (GMT, 47; 95% CI, 35 to 63) (P |
| Databáze: | OpenAIRE |
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