Glucocorticoids suppress formation of erythroid colonies cultured from human fetal liver and umbilical cord blood
| Autor: | A Ibrahim, R. F. Rieder, M. W. Hassan |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
medicine.medical_specialty
Hydrocortisone Biology Umbilical cord General Biochemistry Genetics and Molecular Biology Dexamethasone Fetus Pregnancy hemic and lymphatic diseases Internal medicine medicine Humans Erythropoiesis Globin Incubation Erythropoietin Glucocorticoids Cells Cultured Fetal Blood In vitro Globins Endocrinology medicine.anatomical_structure Colony formation Liver Human fetal Female medicine.drug |
| Zdroj: | Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 169(1) |
| ISSN: | 0037-9727 |
| Popis: | The effect of glucocorticoids on erythroid colony formation in vitro was studied in plasma clot and methylcellulose culture of human fetal liver and umbilical cord blood. At concentrations varying from 10-10 to 10-6M, dexamethasone and hydrocortisone caused 25 to 90% reduction in the number of erythroid colonies present after 5 to 14 days of incubation. This suppression of erythroid colony production by glucocorticoids was not accompanied by an alteration in the ratio of γ and β globin chains synthesized by the erythroid cells. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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