Tetrabenazine fails to antagonize a behavioral effect of cocaine in rhesus monkeys
| Autor: | James H. Woods, Tina L. Sumpter, Lee Koetzner |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.drug_class Tetrabenazine Clinical Biochemistry Tetrabenazina Pharmacology Toxicology Biochemistry Behavioral Neuroscience Cocaine Dopamine Uptake Inhibitors Reaction Time medicine Animals Illicit drug Drug Interactions Biological Psychiatry Monoamine oxidase inhibitor Adrenergic Uptake Inhibitors Behavior Animal business.industry Antagonist Macaca mulatta Mechanism of action Toxicity Conditioning Operant Monoamine transport Female medicine.symptom business medicine.drug |
| Zdroj: | Pharmacology Biochemistry and Behavior. 71:1-5 |
| ISSN: | 0091-3057 |
| DOI: | 10.1016/s0091-3057(01)00532-9 |
| Popis: | For research and therapeutic purposes, a cocaine antagonist is an important drug development goal. The vesicular monoamine transport inhibitor tetrabenazine was tested for interaction with cocaine using food-reinforced responding in rhesus monkeys as an assay. Both tetrabenazine and cocaine suppressed food-maintained behavior individually. However, a low-dose tetrabenazine pretreatment did not alter the rate-suppressing effects of cocaine and cocaine did not alter the rate-suppressing effects of a high dose tetrabenazine pretreatment. Because tetrabenazine interacts with the monoamine oxidase inhibitor deprenyl in this assay, we conclude that cocaine does not produce an effect through vesicular catecholamines in this assay. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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