Incidence and prevalence of multiple sclerosis in persian gulf area: A systematic review and meta-analysis
| Autor: | Yalda Nikanpour, Seán Fitzgerald, Marjan Mansourian, Masoud Etemadifar, Amir Neshatfar |
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| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Multiple Sclerosis MEDLINE 03 medical and health sciences Middle East 0302 clinical medicine Epidemiology medicine Prevalence Humans 030212 general & internal medicine Indian Ocean Persian business.industry Multiple sclerosis Incidence (epidemiology) Incidence General Medicine medicine.disease humanities language.human_language Neurology Meta-analysis language Etiology Neurology (clinical) Age of onset business 030217 neurology & neurosurgery Demography |
| Zdroj: | Multiple sclerosis and related disorders. 40 |
| ISSN: | 2211-0356 |
| Popis: | Background There is an unapprehended diversity in the epidemiology of multiple sclerosis (MS) in different geographical regions. In this study, for the first time, we systematically review the studies estimating the incidence and/or prevalence of MS in the Persian Gulf area. The goal is to obtain the overall incidence and prevalence of MS and elucidate the reasons for the geographical variation. Methods A comprehensive literature search was carried out using MEDLINE and EMBASE through articles published between January 1985 and December 2018 on MS epidemiology in Persian Gulf countries including Bahrain, Iran, Iraq, Kuwait, Oman, Qatar, Saudi Arabia, and the United Arab Emirates. Search terms included 'Multiple sclerosis', 'Incidence', 'Prevalence', 'Epidemiology', 'Persian Gulf', 'Arabian Gulf' and name of each country. Only full-text articles published in English were included. All abstracts were considered and two trained reviewers evaluated the study quality using an assessment tool specifically designed for this study. Results 39 studies met the inclusion criteria. The mean age at disease onset varied in each country and the pooled mean age of onset was 23.11. The overall pooled MS incidence was 5.03/100,000 person-years (95% CI: 0.04 – 10.02). Prevalence was 39.31/100,000 (95% CI: 29.12 – 49.50) and the result of the meta-regression method showed that prevalence increased by 2.3% per year between 1985-2018 (p = 0.04). Quality scores ranged from 4/7 to 8/8. Conclusion The prevalence and incidence of MS in the Persian Gulf region has gone through significant changes during the past decades. This study highlights the need for future studies of MS prevalence and incidence, which will further elucidate the possible etiologies leading to periodical and geographical variations in MS incidence. |
| Databáze: | OpenAIRE |
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