Application of Nanotechnology in Cancer Diagnosis and Therapy - A Mini-Review
| Autor: | Jiangnan Hu, Kankai Wang, Cancan Jin, Anthony Oppong-Gyebi |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
diagnosis
Nanotechnology Review Mini review 03 medical and health sciences Antineoplastic Agents Immunological 0302 clinical medicine Disease severity Neoplasms Biological property Biomarkers Tumor medicine cancer Humans nanomaterials Drug Carriers nanotechnology treatment business.industry Chronic pain Cancer General Medicine medicine.disease Molecular Imaging Nanomedicine Molecular Diagnostic Techniques Target site Cancer cell Cancer management Nanoparticles 030211 gastroenterology & hepatology business |
| Zdroj: | International Journal of Medical Sciences |
| ISSN: | 1449-1907 |
| DOI: | 10.7150/ijms.49801 |
| Popis: | Cancer is a leading cause of death and poor quality of life globally. Even though several strategies are devised to reduce deaths, reduce chronic pain and improve the quality of life, there remains a shortfall in the adequacies of these cancer therapies. Among the cardinal steps towards ensuring optimal cancer treatment are early detection of cancer cells and drug application with high specificity to reduce toxicities. Due to increased systemic toxicities and refractoriness with conventional cancer diagnostic and therapeutic tools, other strategies including nanotechnology are being employed to improve diagnosis and mitigate disease severity. Over the years, immunotherapeutic agents based on nanotechnology have been used for several cancer types to reduce the invasiveness of cancerous cells while sparing healthy cells at the target site. Nanomaterials including carbon nanotubes, polymeric micelles and liposomes have been used in cancer drug design where they have shown considerable pharmacokinetic and pharmacodynamic benefits in cancer diagnosis and treatment. In this review, we outline the commonly used nanomaterials which are employed in cancer diagnosis and therapy. We have highlighted the suitability of these nanomaterials for cancer management based on their physicochemical and biological properties. We further reviewed the challenges that are associated with the various nanomaterials which limit their uses and hamper their translatability into the clinical setting in certain cancer types. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|